Complement component C8 gamma chain
1_MLPPG 6_ TATLL 11_ TLLLA 16_ AGSLG 21_ QKPQR 26_ PRRPA 31_ SPIST 36_ IQPKA 41_ NFDAQ 46_ QFAGT 51_ WLLVA 56_ VGSAC 61_ RFLQE 66_ QGHRA 71_ EATTL 76_ HVAPQ 81_ GTAMA 86_ VSTFR 91_ KLDGI 96_ CWQVR 101_ QLYGD 106_ TGVLG 111_ RFLLQ 116_ ARDAR 121_ GAVHV 126_ VVAET 131_ DYQSF 136_ AVLYL 141_ ERAGQ 146_ LSVKL 151_ YARSL 156_ PVSDS 161_ VLSGF 166_ EQRVQ 171_ EAHLT 176_ EDQIF 181_ YFPKY 186_ GFCEA 191_ ADQFH 196_VLDEV
1: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:26841837, PubMed:27052168, PubMed:30552328). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:30552328). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:30552328). C8G, together with C8A and C8B, inserts into the target membrane, but does not form pores by itself (PubMed:30552328). During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity (PubMed:30552328, PubMed:6833260)