Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-10) (GRP18-27)]
1_MRGRE 6_ LPLVL 11_ LALVL 16_ CLAPR 21_ GRAVP 26_ LPAGG 31_ GTVLT 36_ KMYPR 41_ GNHWA 46_ VGHLM 51_ GKKST 56_ GESSS 61_ VSERG 66_ SLKQQ 71_ LREYI 76_ RWEEA 81_ ARNLL 86_ GLIEA 91_ KENRN 96_ HQPPQ 101_ PKALG 106_ NQQPS 111_ WDSED 116_ SSNFK 121_ DVGSK 126_ GKVGR 131_ LSAPG 136_ SQREG 141_RNPQL
1: Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity)
2: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation