Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
1_MELCG 6_ LGLPR 11_ PPMLL 16_ ALLLA 21_ TLLAA 26_ MLALL 31_ TQVAL 36_ VVQVA 41_ EAARA 46_ PSVSA 51_ KPGPA 56_ LWPLP 61_ LLVKM 66_ TPNLL 71_ HLAPE 76_ NFYIS 81_ HSPNS 86_ TAGPS 91_ CTLLE 96_ EAFRR 101_ YHGYI 106_ FGFYK 111_ WHHEP 116_ AEFQA 121_ KTQVQ 126_ QLLVS 131_ ITLQS 136_ ECDAF 141_ PNISS 146_ DESYT 151_ LLVKE 156_ PVAVL 161_ KANRV 166_ WGALR 171_ GLETF 176_ SQLVY 181_ QDSYG 186_ TFTIN 191_ ESTII 196_ DSPRF 201_ SHRGI 206_ LIDTS 211_ RHYLP 216_ VKIIL 221_ KTLDA 226_ MAFNK 231_ FNVLH 236_ WHIVD 241_ DQSFP 246_ YQSIT 251_ FPELS 256_ NKGSY 261_ SLSHV 266_ YTPND 271_ VRMVI 276_ EYARL 281_ RGIRV 286_ LPEFD 291_ TPGHT 296_ LSWGK 301_ GQKDL 306_ LTPCY 311_ SRQNK 316_ LDSFG 321_ PINPT 326_ LNTTY 331_ SFLTT 336_ FFKEI 341_ SEVFP 346_ DQFIH 351_ LGGDE 356_ VEFKC 361_ WESNP 366_ KIQDF 371_ MRQKG 376_ FGTDF 381_ KKLES 386_ FYIQK 391_ VLDII 396_ ATINK 401_ GSIVW 406_ QEVFD 411_ DKAKL 416_ APGTI 421_ VEVWK 426_ DSAYP 431_ EELSR 436_ VTASG 441_ FPVIL 446_ SAPWY 451_ LDLIS 456_ YGQDW 461_ RKYYK 466_ VEPLD 471_ FGGTQ 476_ KQKQL 481_ FIGGE 486_ ACLWG 491_ EYVDA 496_ TNLTP 501_ RLWPR 506_ ASAVG 511_ ERLWS 516_ SKDVR 521_ DMDDA 526_ YDRLT 531_ RHRCR 536_ MVERG 541_ IAAQP 546_ LYAGY 551_CNHEN
1: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:8123671, PubMed:8672428, PubMed:9694901). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity)