Gene name: PFN1

Uniprot entry:

P07737

Protein names:

Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)

Protein sequence:

1_MAGWN 6_ AYIDN 11_ LMADG 16_ TCQDA 21_ AIVGY 26_ KDSPS 31_ VWAAV 36_ PGKTF 41_ VNITP 46_ AEVGV 51_ LVGKD 56_ RSSFY 61_ VNGLT 66_ LGGQK 71_ CSVIR 76_ DSLLQ 81_ DGEFS 86_ MDLRT 91_ KSTGG 96_ APTFN 101_ VTVTK 106_ TDKTL 111_ VLLMG 116_ KEGVH 121_ GGLIN 126_ KKCYE 131_MASHL

Protein annotations

Protein functions:

1: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR