Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
1_MWQLW 6_ ASLCC 11_ LLVLA 16_ NARSR 21_ PSFHP 26_ LSDEL 31_ VNYVN 36_ KRNTT 41_ WQAGH 46_ NFYNV 51_ DMSYL 56_ KRLCG 61_ TFLGG 66_ PKPPQ 71_ RVMFT 76_ EDLKL 81_ PASFD 86_ AREQW 91_ PQCPT 96_ IKEIR 101_ DQGSC 106_ GSCWA 111_ FGAVE 116_ AISDR 121_ ICIHT 126_ NAHVS 131_ VEVSA 136_ EDLLT 141_ CCGSM 146_ CGDGC 151_ NGGYP 156_ AEAWN 161_ FWTRK 166_ GLVSG 171_ GLYES 176_ HVGCR 181_ PYSIP 186_ PCEHH 191_ VNGSR 196_ PPCTG 201_ EGDTP 206_ KCSKI 211_ CEPGY 216_ SPTYK 221_ QDKHY 226_ GYNSY 231_ SVSNS 236_ EKDIM 241_ AEIYK 246_ NGPVE 251_ GAFSV 256_ YSDFL 261_ LYKSG 266_ VYQHV 271_ TGEMM 276_ GGHAI 281_ RILGW 286_ GVENG 291_ TPYWL 296_ VANSW 301_ NTDWG 306_ DNGFF 311_ KILRG 316_ QDHCG 321_ IESEV 326_ VAGIP 331_RTDQY
1: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105)