Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)
1_MASNV 6_ TNKTD 11_ PRSMN 16_ SRVFI 21_ GNLNT 26_ LVVKK 31_ SDVEA 36_ IFSKY 41_ GKIVG 46_ CSVHK 51_ GFAFV 56_ QYVNE 61_ RNARA 66_ AVAGE 71_ DGRMI 76_ AGQVL 81_ DINLA 86_ AEPKV 91_ NRGKA 96_ GVKRS 101_ AAEMY 106_ GSVTE 111_ HPSPS 116_ PLLSS 121_ SFDLD 126_ YDFQR 131_ DYYDR 136_ MYSYP 141_ ARVPP 146_ PPPIA 151_ RAVVP 156_ SKRQR 161_ VSGNT 166_ SRRGK 171_ SGFNS 176_ KSGQR 181_ GSSKS 186_ GKLKG 191_ DDLQA 196_ IKKEL 201_ TQIKQ 206_ KVDSL 211_ LENLE 216_ KIEKE 221_ QSKQA 226_ VEMKN 231_ DKSEE 236_ EQSSS 241_ SVKKD 246_ ETNVK 251_ MESEG 256_ GADDS 261_ AEEGD 266_ LLDDD 271_ DNEDR 276_ GDDQL 281_ ELIKD 286_ DEKEA 291_ EEGED 296_ DRDSA 301_NGEDD
1: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671)