Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]
1_MGQPS 6_ LTWML 11_ MVVVA 16_ SWFIT 21_ TAATD 26_ TSEAR 31_ WCSEC 36_ HSNAT 41_ CTEDE 46_ AVTTC 51_ TCQEG 56_ FTGDG 61_ LTCVD 66_ LDECA 71_ IPGAH 76_ NCSAN 81_ SSCVN 86_ TPGSF 91_ SCVCP 96_ EGFRL 101_ SPGLG 106_ CTDVD 111_ ECAEP 116_ GLSHC 121_ HALAT 126_ CVNVV 131_ GSYLC 136_ VCPAG 141_ YRGDG 146_ WHCEC 151_ SPGSC 156_ GPGLD 161_ CVPEG 166_ DALVC 171_ ADPCQ 176_ AHRTL 181_ DEYWR 186_ STEYG 191_ EGYAC 196_ DTDLR 201_ GWYRF 206_ VGQGG 211_ ARMAE 216_ TCVPV 221_ LRCNT 226_ AAPMW 231_ LNGTH 236_ PSSDE 241_ GIVSR 246_ KACAH 251_ WSGHC 256_ CLWDA 261_ SVQVK 266_ ACAGG 271_ YYVYN 276_ LTAPP 281_ ECHLA 286_ YCTDP 291_ SSVEG 296_ TCEEC 301_ SIDED 306_ CKSNN 311_ GRWHC 316_ QCKQD 321_ FNITD 326_ ISLLE 331_ HRLEC 336_ GANDM 341_ KVSLG 346_ KCQLK 351_ SLGFD 356_ KVFMY 361_ LSDSR 366_ CSGFN 371_ DRDNR 376_ DWVSV 381_ VTPAR 386_ DGPCG 391_ TVLTR 396_ NETHA 401_ TYSNT 406_ LYLAD 411_ EIIIR 416_ DLNIK 421_ INFAC 426_ SYPLD 431_ MKVSL 436_ KTALQ 441_ PMVSA 446_ LNIRV 451_ GGTGM 456_ FTVRM 461_ ALFQT 466_ PSYTQ 471_ PYQGS 476_ SVTLS 481_ TEAFL 486_ YVGTM 491_ LDGGD 496_ LSRFA 501_ LLMTN 506_ CYATP 511_ SSNAT 516_ DPLKY 521_ FIIQD 526_ RCPHT 531_ RDSTI 536_ QVVEN 541_ GESSQ 546_ GRFSV 551_ QMFRF 556_ AGNYD 561_ LVYLH 566_ CEVYL 571_ CDTMN 576_ EKCKP 581_ TCSGT 586_ RFRSG 591_ SVIDQ 596_ SRVLN 601_ LGPIT 606_ RKGVQ 611_ ATVSR 616_ AFSSL 621_ GLLKV 626_ WLPLL 631_LSATL
1: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515)
2: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals (By similarity). Protects against urinary tract infections by binding to type 1 fimbriated E.coli (PubMed:11134021, PubMed:32616672). Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation (PubMed:11134021, PubMed:32616672). Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens (PubMed:32616672)