Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
1_MGCIK 6_ SKENK 11_ SPAIK 16_ YRPEN 21_ TPEPV 26_ STSVS 31_ HYGAE 36_ PTTVS 41_ PCPSS 46_ SAKGT 51_ AVNFS 56_ SLSMT 61_ PFGGS 66_ SGVTP 71_ FGGAS 76_ SSFSV 81_ VPSSY 86_ PAGLT 91_ GGVTI 96_ FVALY 101_ DYEAR 106_ TTEDL 111_ SFKKG 116_ ERFQI 121_ INNTE 126_ GDWWE 131_ ARSIA 136_ TGKNG 141_ YIPSN 146_ YVAPA 151_ DSIQA 156_ EEWYF 161_ GKMGR 166_ KDAER 171_ LLLNP 176_ GNQRG 181_ IFLVR 186_ ESETT 191_ KGAYS 196_ LSIRD 201_ WDEIR 206_ GDNVK 211_ HYKIR 216_ KLDNG 221_ GYYIT 226_ TRAQF 231_ DTLQK 236_ LVKHY 241_ TEHAD 246_ GLCHK 251_ LTTVC 256_ PTVKP 261_ QTQGL 266_ AKDAW 271_ EIPRE 276_ SLRLE 281_ VKLGQ 286_ GCFGE 291_ VWMGT 296_ WNGTT 301_ KVAIK 306_ TLKPG 311_ TMMPE 316_ AFLQE 321_ AQIMK 326_ KLRHD 331_ KLVPL 336_ YAVVS 341_ EEPIY 346_ IVTEF 351_ MSKGS 356_ LLDFL 361_ KEGDG 366_ KYLKL 371_ PQLVD 376_ MAAQI 381_ ADGMA 386_ YIERM 391_ NYIHR 396_ DLRAA 401_ NILVG 406_ ENLVC 411_ KIADF 416_ GLARL 421_ IEDNE 426_ YTARQ 431_ GAKFP 436_ IKWTA 441_ PEAAL 446_ YGRFT 451_ IKSDV 456_ WSFGI 461_ LQTEL 466_ VTKGR 471_ VPYPG 476_ MVNRE 481_ VLEQV 486_ ERGYR 491_ MPCPQ 496_ GCPES 501_ LHELM 506_ NLCWK 511_ KDPDE 516_ RPTFE 521_ YIQSF 526_ LEDYF 531_ TATEP 536_QYQPG
1: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622)