Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
1_MGCIK 6_ SKGKD 11_ SLSDD 16_ GVDLK 21_ TQPVR 26_ NTERT 31_ IYVRD 36_ PTSNK 41_ QQRPV 46_ PESQL 51_ LPGQR 56_ FQTKD 61_ PEEQG 66_ DIVVA 71_ LYPYD 76_ GIHPD 81_ DLSFK 86_ KGEKM 91_ KVLEE 96_ HGEWW 101_ KAKSL 106_ LTKKE 111_ GFIPS 116_ NYVAK 121_ LNTLE 126_ TEEWF 131_ FKDIT 136_ RKDAE 141_ RQLLA 146_ PGNSA 151_ GAFLI 156_ RESET 161_ LKGSF 166_ SLSVR 171_ DFDPV 176_ HGDVI 181_ KHYKI 186_ RSLDN 191_ GGYYI 196_ SPRIT 201_ FPCIS 206_ DMIKH 211_ YQKQA 216_ DGLCR 221_ RLEKA 226_ CISPK 231_ PQKPW 236_ DKDAW 241_ EIPRE 246_ SIKLV 251_ KRLGA 256_ GQFGE 261_ VWMGY 266_ YNNST 271_ KVAVK 276_ TLKPG 281_ TMSVQ 286_ AFLEE 291_ ANLMK 296_ TLQHD 301_ KLVRL 306_ YAVVT 311_ REEPI 316_ YIITE 321_ YMAKG 326_ SLLDF 331_ LKSDE 336_ GGKVL 341_ LPKLI 346_ DFSAQ 351_ IAEGM 356_ AYIER 361_ KNYIH 366_ RDLRA 371_ ANVLV 376_ SESLM 381_ CKIAD 386_ FGLAR 391_ VIEDN 396_ EYTAR 401_ EGAKF 406_ PIKWT 411_ APEAI 416_ NFGCF 421_ TIKSD 426_ VWSFG 431_ ILLYE 436_ IVTYG 441_ KIPYP 446_ GRTNA 451_ DVMTA 456_ LSQGY 461_ RMPRV 466_ ENCPD 471_ ELYDI 476_ MKMCW 481_ KEKAE 486_ ERPTF 491_ DYLQS 496_ VLDDF 501_ YTATE 506_GQYQQ
1: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138)