Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)
1_MDAIK 6_ KKMQM 11_ LKLDK 16_ ENAID 21_ RAEQA 26_ EADKK 31_ QAEDR 36_ CKQLE 41_ EEQQA 46_ LQKKL 51_ KGTED 56_ EVEKY 61_ SESVK 66_ EAQEK 71_ LEQAE 76_ KKATD 81_ AEADV 86_ ASLNR 91_ RIQLV 96_ EEELD 101_ RAQER 106_ LATAL 111_ QKLEE 116_ AEKAA 121_ DESER 126_ GMKVI 131_ ENRAM 136_ KDEEK 141_ MELQE 146_ MQLKE 151_ AKHIA 156_ EDSDR 161_ KYEEV 166_ ARKLV 171_ ILEGE 176_ LERSE 181_ ERAEV 186_ AESKC 191_ GDLEE 196_ ELKIV 201_ TNNLK 206_ SLEAQ 211_ ADKYS 216_ TKEDK 221_ YEEEI 226_ KLLEE 231_ KLKEA 236_ ETRAE 241_ FAERS 246_ VAKLE 251_ KTIDD 256_ LEDEV 261_ YAQKM 266_ KYKAI 271_ SEELD 276_NALND
1: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization