DNA excision repair protein ERCC-1
1_MDPGK 6_ DKEGV 11_ PQPSG 16_ PPARK 21_ KFVIP 26_ LDEDE 31_ VPPGV 36_ AKPLF 41_ RSTQS 46_ LPTVD 51_ TSAQA 56_ APQTY 61_ AEYAI 66_ SQPLE 71_ GAGAT 76_ CPTGS 81_ EPLAG 86_ ETPNQ 91_ ALKPG 96_ AKSNS 101_ IIVSP 106_ RQRGN 111_ PVLKF 116_ VRNVP 121_ WEFGD 126_ VIPDY 131_ VLGQS 136_ TCALF 141_ LSLRY 146_ HNLHP 151_ DYIHG 156_ RLQSL 161_ GKNFA 166_ LRVLL 171_ VQVDV 176_ KDPQQ 181_ ALKEL 186_ AKMCI 191_ LADCT 196_ LILAW 201_ SPEEA 206_ GRYLE 211_ TYKAY 216_ EQKPA 221_ DLLME 226_ KLEQD 231_ FVSRV 236_ TECLT 241_ TVKSV 246_ NKTDS 251_ QTLLT 256_ TFGSL 261_ EQLIA 266_ ASRED 271_ LALCP 276_ GLGPQ 281_ KARRL 286_ FDVLH 291_EPFLK
1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4
2: Not functional in the nucleotide excision repair pathway
3: Not functional in the nucleotide excision repair pathway
4: Not functional in the nucleotide excision repair pathway