Thrombospondin-1 (Glycoprotein G)
1_MGLAW 6_ GLGVL 11_ FLMHV 16_ CGTNR 21_ IPESG 26_ GDNSV 31_ FDIFE 36_ LTGAA 41_ RKGSG 46_ RRLVK 51_ GPDPS 56_ SPAFR 61_ IEDAN 66_ LIPPV 71_ PDDKF 76_ QDLVD 81_ AVRAE 86_ KGFLL 91_ LASLR 96_ QMKKT 101_ RGTLL 106_ ALERK 111_ DHSGQ 116_ VFSVV 121_ SNGKA 126_ GTLDL 131_ SLTVQ 136_ GKQHV 141_ VSVEE 146_ ALLAT 151_ GQWKS 156_ ITLFV 161_ QEDRA 166_ QLYID 171_ CEKME 176_ NAELD 181_ VPIQS 186_ VFTRD 191_ LASIA 196_ RLRIA 201_ KGGVN 206_ DNFQG 211_ VLQNV 216_ RFVFG 221_ TTPED 226_ ILRNK 231_ GCSSS 236_ TSVLL 241_ TLDNN 246_ VVNGS 251_ SPAIR 256_ TNYIG 261_ HKTKD 266_ LQAIC 271_ GISCD 276_ ELSSM 281_ VLELR 286_ GLRTI 291_ VTTLQ 296_ DSIRK 301_ VTEEN 306_ KELAN 311_ ELRRP 316_ PLCYH 321_ NGVQY 326_ RNNEE 331_ WTVDS 336_ CTECH 341_ CQNSV 346_ TICKK 351_ VSCPI 356_ MPCSN 361_ ATVPD 366_ GECCP 371_ RCWPS 376_ DSADD 381_ GWSPW 386_ SEWTS 391_ CSTSC 396_ GNGIQ 401_ QRGRS 406_ CDSLN 411_ NRCEG 416_ SSVQT 421_ RTCHI 426_ QECDK 431_ RFKQD 436_ GGWSH 441_ WSPWS 446_ SCSVT 451_ CGDGV 456_ ITRIR 461_ LCNSP 466_ SPQMN 471_ GKPCE 476_ GEARE 481_ TKACK 486_ KDACP 491_ INGGW 496_ GPWSP 501_ WDICS 506_ VTCGG 511_ GVQKR 516_ SRLCN 521_ NPTPQ 526_ FGGKD 531_ CVGDV 536_ TENQI 541_ CNKQD 546_ CPIDG 551_ CLSNP 556_ CFAGV 561_ KCTSY 566_ PDGSW 571_ KCGAC 576_ PPGYS 581_ GNGIQ 586_ CTDVD 591_ ECKEV 596_ PDACF 601_ NHNGE 606_ HRCEN 611_ TDPGY 616_ NCLPC 621_ PPRFT 626_ GSQPF 631_ GQGVE 636_ HATAN 641_ KQVCK 646_ PRNPC 651_ TDGTH 656_ DCNKN 661_ AKCNY 666_ LGHYS 671_ DPMYR 676_ CECKP 681_ GYAGN 686_ GIICG 691_ EDTDL 696_ DGWPN 701_ ENLVC 706_ VANAT 711_ YHCKK 716_ DNCPN 721_ LPNSG 726_ QEDYD 731_ KDGIG 736_ DACDD 741_ DDDND 746_ KIPDD 751_ RDNCP 756_ FHYNP 761_ AQYDY 766_ DRDDV 771_ GDRCD 776_ NCPYN 781_ HNPDQ 786_ ADTDN 791_ NGEGD 796_ ACAAD 801_ IDGDG 806_ ILNER 811_ DNCQY 816_ VYNVD 821_ QRDTD 826_ MDGVG 831_ DQCDN 836_ CPLEH 841_ NPDQL 846_ DSDSD 851_ RIGDT 856_ CDNNQ 861_ DIDED 866_ GHQNN 871_ LDNCP 876_ YVPNA 881_ NQADH 886_ DKDGK 891_ GDACD 896_ HDDDN 901_ DGIPD 906_ DKDNC 911_ RLVPN 916_ PDQKD 921_ SDGDG 926_ RGDAC 931_ KDDFD 936_ HDSVP 941_ DIDDI 946_ CPENV 951_ DISET 956_ DFRRF 961_ QMIPL 966_ DPKGT 971_ SQNDP 976_ NWVVR 981_ HQGKE 986_ LVQTV 991_ NCDPG 996_ LAVGY 1001_ DEFNA 1006_ VDFSG 1011_ TFFIN 1016_ TERDD 1021_ DYAGF 1026_ VFGYQ 1031_ SSSRF 1036_ YVVMW 1041_ KQVTQ 1046_ SYWDT 1051_ NPTRA 1056_ QGYSG 1061_ LSVKV 1066_ VNSTT 1071_ GPGEH 1076_ LRNAL 1081_ WHTGN 1086_ TPGQV 1091_ RTLWH 1096_ DPRHI 1101_ GWKDF 1106_ TAYRW 1111_ RLSHR 1116_ PKTGF 1121_ IRVVM 1126_ YEGKK 1131_ IMADS 1136_ GPIYD 1141_ KTYAG 1146_ GRLGL 1151_ FVFSQ 1156_ EMVFF 1161_SDLKY
1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (PubMed:15014436, PubMed:18285447, PubMed:2430973, PubMed:6489349). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:14568985, PubMed:24511121, PubMed:29042481, PubMed:32679764). Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis (PubMed:14568985). Ligand for receptor CD47 (PubMed:19004835, PubMed:8550562). Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS (PubMed:29042481). Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36 (PubMed:10613822, PubMed:11134179, PubMed:1371676). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47 (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:32679764). Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner (PubMed:29042481). Ligand for immunoglobulin-like cell surface receptor SIRPA (PubMed:24511121). Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA (PubMed:24511121). Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging (PubMed:29042481, PubMed:32679764)