Transcription factor Sp1
1_MSDQD 6_ HSMDE 11_ MTAVV 16_ KIEKG 21_ VGGNN 26_ GGNGN 31_ GGGAF 36_ SQARS 41_ SSTGS 46_ SSSTG 51_ GGGQE 56_ SQPSP 61_ LALLA 66_ ATCSR 71_ IESPN 76_ ENSNN 81_ SQGPS 86_ QSGGT 91_ GELDL 96_ TATQL 101_ SQGAN 106_ GWQII 111_ SSSSG 116_ ATPTS 121_ KEQSG 126_ SSTNG 131_ SNGSE 136_ SSKNR 141_ TVSGG 146_ QYVVA 151_ AAPNL 156_ QNQQV 161_ LTGLP 166_ GVMPN 171_ IQYQV 176_ IPQFQ 181_ TVDGQ 186_ QLQFA 191_ ATGAQ 196_ VQQDG 201_ SGQIQ 206_ IIPGA 211_ NQQII 216_ TNRGS 221_ GGNII 226_ AAMPN 231_ LLQQA 236_ VPLQG 241_ LANNV 246_ LSGQT 251_ QYVTN 256_ VPVAL 261_ NGNIT 266_ LLPVN 271_ SVSAA 276_ TLTPS 281_ SQAVT 286_ ISSSG 291_ SQESG 296_ SQPVT 301_ SGTTI 306_ SSASL 311_ VSSQA 316_ SSSSF 321_ FTNAN 326_ SYSTT 331_ TTTSN 336_ MGIMN 341_ FTTSG 346_ SSGTN 351_ SQGQT 356_ PQRVS 361_ GLQGS 366_ DALNI 371_ QQNQT 376_ SGGSL 381_ QAGQQ 386_ KEGEQ 391_ NQQTQ 396_ QQQIL 401_ IQPQL 406_ VQGGQ 411_ ALQAL 416_ QAAPL 421_ SGQTF 426_ TTQAI 431_ SQETL 436_ QNLQL 441_ QAVPN 446_ SGPII 451_ IRTPT 456_ VGPNG 461_ QVSWQ 466_ TLQLQ 471_ NLQVQ 476_ NPQAQ 481_ TITLA 486_ PMQGV 491_ SLGQT 496_ SSSNT 501_ TLTPI 506_ ASAAS 511_ IPAGT 516_ VTVNA 521_ AQLSS 526_ MPGLQ 531_ TINLS 536_ ALGTS 541_ GIQVH 546_ PIQGL 551_ PLAIA 556_ NAPGD 561_ HGAQL 566_ GLHGA 571_ GGDGI 576_ HDDTA 581_ GGEEG 586_ ENSPD 591_ AQPQA 596_ GRRTR 601_ REACT 606_ CPYCK 611_ DSEGR 616_ GSGDP 621_ GKKKQ 626_ HICHI 631_ QGCGK 636_ VYGKT 641_ SHLRA 646_ HLRWH 651_ TGERP 656_ FMCTW 661_ SYCGK 666_ RFTRS 671_ DELQR 676_ HKRTH 681_ TGEKK 686_ FACPE 691_ CPKRF 696_ MRSDH 701_ LSKHI 706_ KTHQN 711_ KKGGP 716_ GVALS 721_ VGTLP 726_ LDSGA 731_ GSEGS 736_ GTATP 741_ SALIT 746_ TNMVA 751_ MEAIC 756_ PEGIA 761_ RLANS 766_ GINVM 771_ QVADL 776_QSINI
1: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity)