Rhodopsin (Opsin-2)
1_MNGTE 6_ GPNFY 11_ VPFSN 16_ ATGVV 21_ RSPFE 26_ YPQYY 31_ LAEPW 36_ QFSML 41_ AAYMF 46_ LLIVL 51_ GFPIN 56_ FLTLY 61_ VTVQH 66_ KKLRT 71_ PLNYI 76_ LLNLA 81_ VADLF 86_ MVLGG 91_ FTSTL 96_ YTSLH 101_ GYFVF 106_ GPTGC 111_ NLEGF 116_ FATLG 121_ GEIAL 126_ WSLVV 131_ LAIER 136_ YVVVC 141_ KPMSN 146_ FRFGE 151_ NHAIM 156_ GVAFT 161_ WVMAL 166_ ACAAP 171_ PLAGW 176_ SRYIP 181_ EGLQC 186_ SCGID 191_ YYTLK 196_ PEVNN 201_ ESFVI 206_ YMFVV 211_ HFTIP 216_ MIIIF 221_ FCYGQ 226_ LVFTV 231_ KEAAA 236_ QQQES 241_ ATTQK 246_ AEKEV 251_ TRMVI 256_ IMVIA 261_ FLICW 266_ VPYAS 271_ VAFYI 276_ FTHQG 281_ SNFGP 286_ IFMTI 291_ PAFFA 296_ KSAAI 301_ YNPVI 306_ YIMMN 311_ KQFRN 316_ CMLTT 321_ ICCGK 326_ NPLGD 331_ DEASA 336_ TVSKT 341_ETSQV
1: Photoreceptor required for image-forming vision at low light intensity (PubMed:7846071, PubMed:8107847). Required for photoreceptor cell viability after birth (PubMed:12566452, PubMed:2215617). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:26200343, PubMed:28524165, PubMed:28753425, PubMed:8107847). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:26200343, PubMed:28524165)