Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (p75 ICD) (CD antigen CD271)
1_MGAGA 6_ TGRAM 11_ DGPRL 16_ LLLLL 21_ LGVSL 26_ GGAKE 31_ ACPTG 36_ LYTHS 41_ GECCK 46_ ACNLG 51_ EGVAQ 56_ PCGAN 61_ QTVCE 66_ PCLDS 71_ VTFSD 76_ VVSAT 81_ EPCKP 86_ CTECV 91_ GLQSM 96_ SAPCV 101_ EADDA 106_ VCRCA 111_ YGYYQ 116_ DETTG 121_ RCEAC 126_ RVCEA 131_ GSGLV 136_ FSCQD 141_ KQNTV 146_ CEECP 151_ DGTYS 156_ DEANH 161_ VDPCL 166_ PCTVC 171_ EDTER 176_ QLREC 181_ TRWAD 186_ AECEE 191_ IPGRW 196_ ITRST 201_ PPEGS 206_ DSTAP 211_ STQEP 216_ EAPPE 221_ QDLIA 226_ STVAG 231_ VVTTV 236_ MGSSQ 241_ PVVTR 246_ GTTDN 251_ LIPVY 256_ CSILA 261_ AVVVG 266_ LVAYI 271_ AFKRW 276_ NSCKQ 281_ NKQGA 286_ NSRPV 291_ NQTPP 296_ PEGEK 301_ LHSDS 306_ GISVD 311_ SQSLH 316_ DQQPH 321_ TQTAS 326_ GQALK 331_ GDGGL 336_ YSSLP 341_ PAKRE 346_ EVEKL 351_ LNGSA 356_ GDTWR 361_ HLAGE 366_ LGYQP 371_ EHIDS 376_ FTHEA 381_ CPVRA 386_ LLASW 391_ ATQDS 396_ ATLDA 401_ LLAAL 406_ RRIQR 411_ ADLVE 416_ SLCSE 421_STATS
1: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094)