Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)
1_MFNSM 6_ TPPPI 11_ SSYGE 16_ PCCLR 21_ PLPSQ 26_ GAPSV 31_ GTEGL 36_ SGPPF 41_ CHQAN 46_ LMSGP 51_ HSYGP 56_ ARETN 61_ SCTEG 66_ PLFSS 71_ PRSAV 76_ KLTKK 81_ RALSI 86_ SPLSD 91_ ASLDL 96_ QTVIR 101_ TSPSS 106_ LVAFI 111_ NSRCT 116_ SPGGS 121_ YGHLS 126_ IGTMS 131_ PSLGF 136_ PAQMN 141_ HQKGP 146_ SPSFG 151_ VQPCG 156_ PHDSA 161_ RGGMI 166_ PHPQS 171_ RGPFP 176_ TCQLK 181_ SELDM 186_ LVGKC 191_ REEPL 196_ EGDMS 201_ SPNST 206_ GIQDP 211_ LLGML 216_ DGRED 221_ LEREE 226_ KREPE 231_ SVYET 236_ DCRWD 241_ GCSQE 246_ FDSQE 251_ QLVHH 256_ INSEH 261_ IHGER 266_ KEFVC 271_ HWGGC 276_ SRELR 281_ PFKAQ 286_ YMLVV 291_ HMRRH 296_ TGEKP 301_ HKCTF 306_ EGCRK 311_ SYSRL 316_ ENLKT 321_ HLRSH 326_ TGEKP 331_ YMCEH 336_ EGCSK 341_ AFSNA 346_ SDRAK 351_ HQNRT 356_ HSNEK 361_ PYVCK 366_ LPGCT 371_ KRYTD 376_ PSSLR 381_ KHVKT 386_ VHGPD 391_ AHVTK 396_ RHRGD 401_ GPLPR 406_ APSIS 411_ TVEPK 416_ REREG 421_ GPIRE 426_ ESRLT 431_ VPEGA 436_ MKPQP 441_ SPGAQ 446_ SSCSS 451_ DHSPA 456_ GSAAN 461_ TDSGV 466_ EMTGN 471_ AGGST 476_ EDLSS 481_ LDEGP 486_ CIAGT 491_ GLSTL 496_ RRLEN 501_ LRLDQ 506_ LHQLR 511_ PIGTR 516_ GLKLP 521_ SLSHT 526_ GTTVS 531_ RRVGP 536_ PVSLE 541_ RRSSS 546_ SSSIS 551_ SAYTV 556_ SRRSS 561_ LASPF 566_ PPGSP 571_ PENGA 576_ SSLPG 581_ LMPAQ 586_ HYLLR 591_ ARYAS 596_ ARGGG 601_ TSPTA 606_ ASSLD 611_ RIGGL 616_ PMPPW 621_ RSRAE 626_ YPGYN 631_ PNAGV 636_ TRRAS 641_ DPAQA 646_ ADRPA 651_ PARVQ 656_ RFKSL 661_ GCVHT 666_ PPTVA 671_ GGGQN 676_ FDPYL 681_ PTSVY 686_ SPQPP 691_ SITEN 696_ AAMDA 701_ RGLQE 706_ EPEVG 711_ TSMVG 716_ SGLNP 721_ YMDFP 726_ PTDTL 731_ GYGGP 736_ EGAAA 741_ EPYGA 746_ RGPGS 751_ LPLGP 756_ GPPTN 761_ YGPNP 766_ CPQQA 771_ SYPDP 776_ TQETW 781_ GEFPS 786_ HSGLY 791_ PGPKA 796_ LGGTY 801_ SQCPR 806_ LEHYG 811_ QVQVK 816_ PEQGC 821_ PVGSD 826_ STGLA 831_ PCLNA 836_ HPSEG 841_ PPHPQ 846_ PLFSH 851_ YPQPS 856_ PPQYL 861_ QSGPY 866_ TQPPP 871_ DYLPS 876_ EPRPC 881_ LDFDS 886_ PTHST 891_ GQLKA 896_ QLVCN 901_ YVQSQ 906_ QELLW 911_ EGGGR 916_ EDAPA 921_ QEPSY 926_ QSPKF 931_ LGGSQ 936_ VSPSR 941_ AKAPV 946_ NTYGP 951_ GFGPN 956_ LPNHK 961_ SGSYP 966_ TPSPC 971_ HENFV 976_ VGANR 981_ ASHRA 986_ AAPPR 991_ LLPPL 996_ PTCYG 1001_ PLKVG 1006_ GTNPS 1011_ CGHPE 1016_ VGRLG 1021_ GGPAL 1026_ YPPPE 1031_ GQVCN 1036_ PLDSL 1041_ DLDNT 1046_ QLDFV 1051_ AILDE 1056_ PQGLS 1061_ PPPSH 1066_ DQRGS 1071_ SGHTP 1076_ PPSGP 1081_ PNMAV 1086_ GNMSV 1091_ LLRSL 1096_ PGETE 1101_FLNSS
1: Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407)
2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration