Muscarinic acetylcholine receptor M2
1_MNNST 6_ NSSNN 11_ SLALT 16_ SPYKT 21_ FEVVF 26_ IVLVA 31_ GSLSL 36_ VTIIG 41_ NILVM 46_ VSIKV 51_ NRHLQ 56_ TVNNY 61_ FLFSL 66_ ACADL 71_ IIGVF 76_ SMNLY 81_ TLYTV 86_ IGYWP 91_ LGPVV 96_ CDLWL 101_ ALDYV 106_ VSNAS 111_ VMNLL 116_ IISFD 121_ RYFCV 126_ TKPLT 131_ YPVKR 136_ TTKMA 141_ GMMIA 146_ AAWVL 151_ SFILW 156_ APAIL 161_ FWQFI 166_ VGVRT 171_ VEDGE 176_ CYIQF 181_ FSNAA 186_ VTFGT 191_ AIAAF 196_ YLPVI 201_ IMTVL 206_ YWHIS 211_ RASKS 216_ RIKKD 221_ KKEPV 226_ ANQDP 231_ VSPSL 236_ VQGRI 241_ VKPNN 246_ NNMPS 251_ SDDGL 256_ EHNKI 261_ QNGKA 266_ PRDPV 271_ TENCV 276_ QGEEK 281_ ESSND 286_ STSVS 291_ AVASN 296_ MRDDE 301_ ITQDE 306_ NTVST 311_ SLGHS 316_ KDENS 321_ KQTCI 326_ RIGTK 331_ TPKSD 336_ SCTPT 341_ NTTVE 346_ VVGSS 351_ GQNGD 356_ EKQNI 361_ VARKI 366_ VKMTK 371_ QPAKK 376_ KPPPS 381_ REKKV 386_ TRTIL 391_ AILLA 396_ FIITW 401_ APYNV 406_ MVLIN 411_ TFCAP 416_ CIPNT 421_ VWTIG 426_ YWLCY 431_ INSTI 436_ NPACY 441_ ALCNA 446_ TFKKT 451_ FKHLL 456_ MCHYK 461_NIGAT
1: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol