4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)
1_MELQP 6_ PEASI 11_ AVVSI 16_ PRQLP 21_ GSHSE 26_ AGVQG 31_ LSAGD 36_ DSELG 41_ SHCVA 46_ QTGLE 51_ LLASG 56_ DPLPS 61_ ASQNA 66_ EMIET 71_ GSDCV 76_ TQAGL 81_ QLLAS 86_ SDPPA 91_ LASKN 96_ AEVTG 101_ TMSQD 106_ TEVDM 111_ KEVEL 116_ NELEP 121_ EKQPM 126_ NAASG 131_ AAMSL 136_ AGAEK 141_ NGLVK 146_ IKVAE 151_ DEAEA 156_ AAAAK 161_ FTGLS 166_ KEELL 171_ KVAGS 176_ PGWVR 181_ TRWAL 186_ LLLFW 191_ LGWLG 196_ MLAGA 201_ VVIIV 206_ RAPRC 211_ RELPA 216_ QKWWH 221_ TGALY 226_ RIGDL 231_ QAFQG 236_ HGAGN 241_ LAGLK 246_ GRLDY 251_ LSSLK 256_ VKGLV 261_ LGPIH 266_ KNQKD 271_ DVAQT 276_ DLLQI 281_ DPNFG 286_ SKEDF 291_ DSLLQ 296_ SAKKK 301_ SIRVI 306_ LDLTP 311_ NYRGE 316_ NSWFS 321_ TQVDT 326_ VATKV 331_ KDALE 336_ FWLQA 341_ GVDGF 346_ QVRDI 351_ ENLKD 356_ ASSFL 361_ AEWQN 366_ ITKGF 371_ SEDRL 376_ LIAGT 381_ NSSDL 386_ QQILS 391_ LLESN 396_ KDLLL 401_ TSSYL 406_ SDSGS 411_ TGEHT 416_ KSLVT 421_ QYLNA 426_ TGNRW 431_ CSWSL 436_ SQARL 441_ LTSFL 446_ PAQLL 451_ RLYQL 456_ MLFTL 461_ PGTPV 466_ FSYGD 471_ EIGLD 476_ AAALP 481_ GQPME 486_ APVML 491_ WDESS 496_ FPDIP 501_ GAVSA 506_ NMTVK 511_ GQSED 516_ PGSLL 521_ SLFRR 526_ LSDQR 531_ SKERS 536_ LLHGD 541_ FHAFS 546_ AGPGL 551_ FSYIR 556_ HWDQN 561_ ERFLV 566_ VLNFG 571_ DVGLS 576_ AGLQA 581_ SDLPA 586_ SASLP 591_ AKADL 596_ LLSTQ 601_ PGREE 606_ GSPLE 611_ LERLK 616_ LEPHE 621_GLLLR
1: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115)
2: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis
3: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells