Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)
1_MTLGR 6_ RLACL 11_ FLACV 16_ LPALL 21_ LGGTA 26_ LASEI 31_ VGGRR 36_ ARPHA 41_ WPFMV 46_ SLQLR 51_ GGHFC 56_ GATLI 61_ APNFV 66_ MSAAH 71_ CVANV 76_ NVRAV 81_ RVVLG 86_ AHNLS 91_ RREPT 96_ RQVFA 101_ VQRIF 106_ ENGYD 111_ PVNLL 116_ NDIVI 121_ LQLNG 126_ SATIN 131_ ANVQV 136_ AQLPA 141_ QGRRL 146_ GNGVQ 151_ CLAMG 156_ WGLLG 161_ RNRGI 166_ ASVLQ 171_ ELNVT 176_ VVTSL 181_ CRRSN 186_ VCTLV 191_ RGRQA 196_ GVCFG 201_ DSGSP 206_ LVCNG 211_ LIHGI 216_ ASFVR 221_ GGCAS 226_ GLYPD 231_ AFAPV 236_ AQFVN 241_ WIDSI 246_ IQRSE 251_ DNPCP 256_ HPRDP 261_DPASR
1: Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (PubMed:36899106). Promotes blood coagulation (PubMed:20676107). Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (PubMed:25211214, PubMed:9111081). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI) (PubMed:20676107, PubMed:25211214). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984)