72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]
1_MEALM 6_ ARGAL 11_ TGPLR 16_ ALCLL 21_ GCLLS 26_ HAAAA 31_ PSPII 36_ KFPGD 41_ VAPKT 46_ DKELA 51_ VQYLN 56_ TFYGC 61_ PKESC 66_ NLFVL 71_ KDTLK 76_ KMQKF 81_ FGLPQ 86_ TGDLD 91_ QNTIE 96_ TMRKP 101_ RCGNP 106_ DVANY 111_ NFFPR 116_ KPKWD 121_ KNQIT 126_ YRIIG 131_ YTPDL 136_ DPETV 141_ DDAFA 146_ RAFQV 151_ WSDVT 156_ PLRFS 161_ RIHDG 166_ EADIM 171_ INFGR 176_ WEHGD 181_ GYPFD 186_ GKDGL 191_ LAHAF 196_ APGTG 201_ VGGDS 206_ HFDDD 211_ ELWTL 216_ GEGQV 221_ VRVKY 226_ GNADG 231_ EYCKF 236_ PFLFN 241_ GKEYN 246_ SCTDT 251_ GRSDG 256_ FLWCS 261_ TTYNF 266_ EKDGK 271_ YGFCP 276_ HEALF 281_ TMGGN 286_ AEGQP 291_ CKFPF 296_ RFQGT 301_ SYDSC 306_ TTEGR 311_ TDGYR 316_ WCGTT 321_ EDYDR 326_ DKKYG 331_ FCPET 336_ AMSTV 341_ GGNSE 346_ GAPCV 351_ FPFTF 356_ LGNKY 361_ ESCTS 366_ AGRSD 371_ GKMWC 376_ ATTAN 381_ YDDDR 386_ KWGFC 391_ PDQGY 396_ SLFLV 401_ AAHEF 406_ GHAMG 411_ LEHSQ 416_ DPGAL 421_ MAPIY 426_ TYTKN 431_ FRLSQ 436_ DDIKG 441_ IQELY 446_ GASPD 451_ IDLGT 456_ GPTPT 461_ LGPVT 466_ PEICK 471_ QDIVF 476_ DGIAQ 481_ IRGEI 486_ FFFKD 491_ RFIWR 496_ TVTPR 501_ DKPMG 506_ PLLVA 511_ TFWPE 516_ LPEKI 521_ DAVYE 526_ APQEE 531_ KAVFF 536_ AGNEY 541_ WIYSA 546_ STLER 551_ GYPKP 556_ LTSLG 561_ LPPDV 566_ QRVDA 571_ AFNWS 576_ KNKKT 581_ YIFAG 586_ DKFWR 591_ YNEVK 596_ KKMDP 601_ GFPKL 606_ IADAW 611_ NAIPD 616_ NLDAV 621_ VDLQG 626_ GGHSY 631_ FFKGA 636_ YYLKL 641_ ENQSL 646_ KSVKF 651_GSIKS
1: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14
2: PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels
3: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways