Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1)
1_MKSLP 6_ ILLLL 11_ CVAVC 16_ SAYPL 21_ DGAAR 26_ GEDTS 31_ MNLVQ 36_ KYLEN 41_ YYDLK 46_ KDVKQ 51_ FVRRK 56_ DSGPV 61_ VKKIR 66_ EMQKF 71_ LGLEV 76_ TGKLD 81_ SDTLE 86_ VMRKP 91_ RCGVP 96_ DVGHF 101_ RTFPG 106_ IPKWR 111_ KTHLT 116_ YRIVN 121_ YTPDL 126_ PKDAV 131_ DSAVE 136_ KALKV 141_ WEEVT 146_ PLTFS 151_ RLYEG 156_ EADIM 161_ ISFAV 166_ REHGD 171_ FYPFD 176_ GPGNV 181_ LAHAY 186_ APGPG 191_ INGDA 196_ HFDDD 201_ EQWTK 206_ DTTGT 211_ NLFLV 216_ AAHEI 221_ GHSLG 226_ LFHSA 231_ NTEAL 236_ MYPLY 241_ HSLTD 246_ LTRFR 251_ LSQDD 256_ INGIQ 261_ SLYGP 266_ PPDSP 271_ ETPLV 276_ PTEPV 281_ PPEPG 286_ TPANC 291_ DPALS 296_ FDAVS 301_ TLRGE 306_ ILIFK 311_ DRHFW 316_ RKSLR 321_ KLEPE 326_ LHLIS 331_ SFWPS 336_ LPSGV 341_ DAAYE 346_ VTSKD 351_ LVFIF 356_ KGNQF 361_ WAIRG 366_ NEVRA 371_ GYPRG 376_ IHTLG 381_ FPPTV 386_ RKIDA 391_ AISDK 396_ EKNKT 401_ YFFVE 406_ DKYWR 411_ FDEKR 416_ NSMEP 421_ GFPKQ 426_ IAEDF 431_ PGIDS 436_ KIDAV 441_ FEEFG 446_ FFYFF 451_ TGSSQ 456_ LEFDP 461_ NAKKV 466_ THTLK 471_SNSWL
1: Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9 (PubMed:11029580, PubMed:1371271). Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway (PubMed:2383557). Also acts intracellularly (PubMed:22265821). For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage (PubMed:21330369). In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1 (PubMed:35940311). Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311)