Glutathione S-transferase A1 (EC 2.5.1.18) (13-hydroperoxyoctadecadienoate peroxidase) (EC 1.11.1.-) (Androst-5-ene-3,17-dione isomerase) (EC 5.3.3.-) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed]
1_MAEKP 6_ KLHYF 11_ NARGR 16_ MESTR 21_ WLLAA 26_ AGVEF 31_ EEKFI 36_ KSAED 41_ LDKLR 46_ NDGYL 51_ MFQQV 56_ PMVEI 61_ DGMKL 66_ VQTRA 71_ ILNYI 76_ ASKYN 81_ LYGKD 86_ IKERA 91_ LIDMY 96_ IEGIA 101_ DLGEM 106_ ILLLP 111_ VCPPE 116_ EKDAK 121_ LALIK 126_ EKIKN 131_ RYFPA 136_ FEKVL 141_ KSHGQ 146_ DYLVG 151_ NKLSR 156_ ADIHL 161_ VELLY 166_ YVEEL 171_ DSSLI 176_ SSFPL 181_ LKALK 186_ TRISN 191_ LPTVK 196_ KFLQP 201_ GSPRK 206_ PPMDE 211_ KSLEE 216_ARKIF
1: Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487)