All-trans-retinol dehydrogenase [NAD(+)] ADH4 (EC 1.1.1.105) (Alcohol dehydrogenase 4) (Alcohol dehydrogenase class II pi chain)
1_MGTKG 6_ KVIKC 11_ KAAIA 16_ WEAGK 21_ PLCIE 26_ EVEVA 31_ PPKAH 36_ EVRIQ 41_ IIATS 46_ LCHTD 51_ ATVID 56_ SKFEG 61_ LAFPV 66_ IVGHE 71_ AAGIV 76_ ESIGP 81_ GVTNV 86_ KPGDK 91_ VIPLY 96_ APLCR 101_ KCKFC 106_ LSPLT 111_ NLCGK 116_ ISNLK 121_ SPASD 126_ QQLME 131_ DKTSR 136_ FTCKG 141_ KPVYH 146_ FFGTS 151_ TFSQY 156_ TVVSD 161_ INLAK 166_ IDDDA 171_ NLERV 176_ CLLGC 181_ GFSTG 186_ YGAAI 191_ NNAKV 196_ TPGST 201_ CAVFG 206_ LGGVG 211_ LSAVM 216_ GCKAA 221_ GASRI 226_ IGIDI 231_ NSEKF 236_ VKAKA 241_ LGATD 246_ CLNPR 251_ DLHKP 256_ IQEVI 261_ IELTK 266_ GGVDF 271_ ALDCA 276_ GGSET 281_ MKAAL 286_ DCTTA 291_ GWGSC 296_ TFIGV 301_ AAGSK 306_ GLTIF 311_ PEELI 316_ IGRTI 321_ NGTFF 326_ GGWKS 331_ VDSIP 336_ KLVTD 341_ YKNKK 346_ FNLDA 351_ LVTHT 356_ LPFDK 361_ ISEAF 366_ DLMNQ 371_GKSVR
1: Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444)