Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10)
1_MGKSE 6_ SQMDI 11_ TDINT 16_ PKPKK 21_ KQRWT 26_ PLEIS 31_ LSVLV 36_ LLLTI 41_ IAVTM 46_ IALYA 51_ TYDDG 56_ ICKSS 61_ DCIKS 66_ AARLI 71_ QNMDA 76_ TTEPC 81_ TDFFK 86_ YACGG 91_ WLKRN 96_ VIPET 101_ SSRYG 106_ NFDIL 111_ RDELE 116_ VVLKD 121_ VLQEP 126_ KTEDI 131_ VAVQK 136_ AKALY 141_ RSCIN 146_ ESAID 151_ SRGGE 156_ PLLKL 161_ LPDIY 166_ GWPVA 171_ TENWE 176_ QKYGA 181_ SWTAE 186_ KAIAQ 191_ LNSKY 196_ GKKVL 201_ INLFV 206_ GTDDK 211_ NSVNH 216_ VIHID 221_ QPRLG 226_ LPSRD 231_ YYECT 236_ GIYKE 241_ ACTAY 246_ VDFMI 251_ SVARL 256_ IRQEE 261_ RLPID 266_ ENQLA 271_ LEMNK 276_ VMELE 281_ KEIAN 286_ ATAKP 291_ EDRND 296_ PMLLY 301_ NKMTL 306_ AQIQN 311_ NFSLE 316_ INGKP 321_ FSWLN 326_ FTNEI 331_ MSTVN 336_ ISITN 341_ EEDVV 346_ VYAPE 351_ YLTKL 356_ KPILT 361_ KYSAR 366_ DLQNL 371_ MSWRF 376_ IMDLV 381_ SSLSR 386_ TYKES 391_ RNAFR 396_ KALYG 401_ TTSET 406_ ATWRR 411_ CANYV 416_ NGNME 421_ NAVGR 426_ LYVEA 431_ AFAGE 436_ SKHVV 441_ EDLIA 446_ QIREV 451_ FIQTL 456_ DDLTW 461_ MDAET 466_ KKRAE 471_ EKALA 476_ IKERI 481_ GYPDD 486_ IVSND 491_ NKLNN 496_ EYLEL 501_ NYKED 506_ EYFEN 511_ IIQNL 516_ KFSQS 521_ KQLKK 526_ LREKV 531_ DKDEW 536_ ISGAA 541_ VVNAF 546_ YSSGR 551_ NQIVF 556_ PAGIL 561_ QPPFF 566_ SAQQS 571_ NSLNY 576_ GGIGM 581_ VIGHE 586_ ITHGF 591_ DDNGR 596_ NFNKD 601_ GDLVD 606_ WWTQQ 611_ SASNF 616_ KEQSQ 621_ CMVYQ 626_ YGNFS 631_ WDLAG 636_ GQHLN 641_ GINTL 646_ GENIA 651_ DNGGL 656_ GQAYR 661_ AYQNY 666_ IKKNG 671_ EEKLL 676_ PGLDL 681_ NHKQL 686_ FFLNF 691_ AQVWC 696_ GTYRP 701_ EYAVN 706_ SIKTD 711_ VHSPG 716_ NFRII 721_ GTLQN 726_ SAEFS 731_ EAFHC 736_ RKNSY 741_MNPEK
1: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:6208535, PubMed:6349683, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991, PubMed:6349683). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675, PubMed:6349683). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:16254193, PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573)