Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]
1_MARAL 6_ CPLQA 11_ LWLLE 16_ WVLLL 21_ LGPCA 26_ APPAW 31_ ALNLD 36_ PVQLT 41_ FYAGP 46_ NGSQF 51_ GFSLD 56_ FHKDS 61_ HGRVA 66_ IVVGA 71_ PRTLG 76_ PSQEE 81_ TGGVF 86_ LCPWR 91_ AEGGQ 96_ CPSLL 101_ FDLRD 106_ ETRNV 111_ GSQTL 116_ QTFKA 121_ RQGLG 126_ ASVVS 131_ WSDVI 136_ VACAP 141_ WQHWN 146_ VLEKT 151_ EEAEK 156_ TPVGS 161_ CFLAQ 166_ PESGR 171_ RAEYS 176_ PCRGN 181_ TLSRI 186_ YVEND 191_ FSWDK 196_ RYCEA 201_ GFSSV 206_ VTQAG 211_ ELVLG 216_ APGGY 221_ YFLGL 226_ LAQAP 231_ VADIF 236_ SSYRP 241_ GILLW 246_ HVSSQ 251_ SLSFD 256_ SSNPE 261_ YFDGY 266_ WGYSV 271_ AVGEF 276_ DGDLN 281_ TTEYV 286_ VGAPT 291_ WSWTL 296_ GAVEI 301_ LDSYY 306_ QRLHR 311_ LRGEQ 316_ MASYF 321_ GHSVA 326_ VTDVN 331_ GDGRH 336_ DLLVG 341_ APLYM 346_ ESRAD 351_ RKLAE 356_ VGRVY 361_ LFLQP 366_ RGPHA 371_ LGAPS 376_ LLLTG 381_ TQLYG 386_ RFGSA 391_ IAPLG 396_ DLDRD 401_ GYNDI 406_ AVAAP 411_ YGGPS 416_ GRGQV 421_ LVFLG 426_ QSEGL 431_ RSRPS 436_ QVLDS 441_ PFPTG 446_ SAFGF 451_ SLRGA 456_ VDIDD 461_ NGYPD 466_ LIVGA 471_ YGANQ 476_ VAVYR 481_ AQPVV 486_ KASVQ 491_ LLVQD 496_ SLNPA 501_ VKSCV 506_ LPQTK 511_ TPVSC 516_ FNIQM 521_ CVGAT 526_ GHNIP 531_ QKLSL 536_ NAELQ 541_ LDRQK 546_ PRQGR 551_ RVLLL 556_ GSQQA 561_ GTTLN 566_ LDLGG 571_ KHSPI 576_ CHTTM 581_ AFLRD 586_ EADFR 591_ DKLSP 596_ IVLSL 601_ NVSLP 606_ PTEAG 611_ MAPAV 616_ VLHGD 621_ THVQE 626_ QTRIV 631_ LDCGE 636_ DDVCV 641_ PQLQL 646_ TASVT 651_ GSPLL 656_ VGADN 661_ VLELQ 666_ MDAAN 671_ EGEGA 676_ YEAEL 681_ AVHLP 686_ QGAHY 691_ MRALS 696_ NVEGF 701_ ERLIC 706_ NQKKE 711_ NETRV 716_ VLCEL 721_ GNPMK 726_ KNAQI 731_ GIAML 736_ VSVGN 741_ LEEAG 746_ ESVSF 751_ QLQIR 756_ SKNSQ 761_ NPNSK 766_ IVLLD 771_ VPVRA 776_ EAQVE 781_ LRGNS 786_ FPASL 791_ VVAAE 796_ EGERE 801_ QNSLD 806_ SWGPK 811_ VEHTY 816_ ELHNN 821_ GPGTV 826_ NGLHL 831_ SIHLP 836_ GQSQP 841_ SDLLY 846_ ILDIQ 851_ PQGGL 856_ QCFPQ 861_ PPVNP 866_ LKVDW 871_ GLPIP 876_ SPSPI 881_ HPAHH 886_ KRDRR 891_ QIFLP 896_ EPEQP 901_ SRLQD 906_ PVLVS 911_ CDSAP 916_ CTVVQ 921_ CDLQE 926_ MARGQ 931_ RAMVT 936_ VLAFL 941_ WLPSL 946_ YQRPL 951_ DQFVL 956_ QSHAW 961_ FNVSS 966_ LPYAV 971_ PPLSL 976_ PRGEA 981_ QVWTQ 986_ LLRAL 991_ EERAI 996_ PIWWV 1001_ LVGVL 1006_ GGLLL 1011_ LTILV 1016_ LAMWK 1021_ VGFFK 1026_ RNRPP 1031_LEEDD
1: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity)