Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]
1_MERAS 6_ CLLLL 11_ LLPLV 16_ HVSAT 21_ TPEPC 26_ ELDDE 31_ DFRCV 36_ CNFSE 41_ PQPDW 46_ SEAFQ 51_ CVSAV 56_ EVEIH 61_ AGGLN 66_ LEPFL 71_ KRVDA 76_ DADPR 81_ QYADT 86_ VKALR 91_ VRRLT 96_ VGAAQ 101_ VPAQL 106_ LVGAL 111_ RVLAY 116_ SRLKE 121_ LTLED 126_ LKITG 131_ TMPPL 136_ PLEAT 141_ GLALS 146_ SLRLR 151_ NVSWA 156_ TGRSW 161_ LAELQ 166_ QWLKP 171_ GLKVL 176_ SIAQA 181_ HSPAF 186_ SCEQV 191_ RAFPA 196_ LTSLD 201_ LSDNP 206_ GLGER 211_ GLMAA 216_ LCPHK 221_ FPAIQ 226_ NLALR 231_ NTGME 236_ TPTGV 241_ CAALA 246_ AAGVQ 251_ PHSLD 256_ LSHNS 261_ LRATV 266_ NPSAP 271_ RCMWS 276_ SALNS 281_ LNLSF 286_ AGLEQ 291_ VPKGL 296_ PAKLR 301_ VLDLS 306_ CNRLN 311_ RAPQP 316_ DELPE 321_ VDNLT 326_ LDGNP 331_ FLVPG 336_ TALPH 341_ EGSMN 346_ SGVVP 351_ ACARS 356_ TLSVG 361_ VSGTL 366_VLLQG
1: Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:22265692, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187)