Collagen alpha-2(IV) chain [Cleaved into: Canstatin]
1_MGRDQ 6_ RAVAG 11_ PALRR 16_ WLLLG 21_ TVTVG 26_ FLAQS 31_ VLAGV 36_ KKFDV 41_ PCGGR 46_ DCSGG 51_ CQCYP 56_ EKGGR 61_ GQPGP 66_ VGPQG 71_ YNGPP 76_ GLQGF 81_ PGLQG 86_ RKGDK 91_ GERGA 96_ PGVTG 101_ PKGDV 106_ GARGV 111_ SGFPG 116_ ADGIP 121_ GHPGQ 126_ GGPRG 131_ RPGYD 136_ GCNGT 141_ QGDSG 146_ PQGPP 151_ GSEGF 156_ TGPPG 161_ PQGPK 166_ GQKGE 171_ PYALP 176_ KEERD 181_ RYRGE 186_ PGEPG 191_ LVGFQ 196_ GPPGR 201_ PGHVG 206_ QMGPV 211_ GAPGR 216_ PGPPG 221_ PPGPK 226_ GQQGN 231_ RGLGF 236_ YGVKG 241_ EKGDV 246_ GQPGP 251_ NGIPS 256_ DTLHP 261_ IIAPT 266_ GVTFH 271_ PDQYK 276_ GEKGS 281_ EGEPG 286_ IRGIS 291_ LKGEE 296_ GIMGF 301_ PGLRG 306_ YPGLS 311_ GEKGS 316_ PGQKG 321_ SRGLD 326_ GYQGP 331_ DGPRG 336_ PKGEA 341_ GDPGP 346_ PGLPA 351_ YSPHP 356_ SLAKG 361_ ARGDP 366_ GFPGA 371_ QGEPG 376_ SQGEP 381_ GDPGL 386_ PGPPG 391_ LSIGD 396_ GDQRR 401_ GLPGE 406_ MGPKG 411_ FIGDP 416_ GIPAL 421_ YGGPP 426_ GPDGK 431_ RGPPG 436_ PPGLP 441_ GPPGP 446_ DGFLF 451_ GLKGA 456_ KGRAG 461_ FPGLP 466_ GSPGA 471_ RGPKG 476_ WKGDA 481_ GECRC 486_ TEGDE 491_ AIKGL 496_ PGLPG 501_ PKGFA 506_ GINGE 511_ PGRKG 516_ DRGDP 521_ GQHGL 526_ PGFPG 531_ LKGVP 536_ GNIGA 541_ PGPKG 546_ AKGDS 551_ RTITT 556_ KGERG 561_ QPGVP 566_ GVPGM 571_ KGDDG 576_ SPGRD 581_ GLDGF 586_ PGLPG 591_ PPGDG 596_ IKGPP 601_ GDPGY 606_ PGIPG 611_ TKGTP 616_ GEMGP 621_ PGLGL 626_ PGLKG 631_ QRGFP 636_ GDAGL 641_ PGPPG 646_ FLGPP 651_ GPAGT 656_ PGQID 661_ CDTDV 666_ KRAVG 671_ GDRQE 676_ AIQPG 681_ CIGGP 686_ KGLPG 691_ LPGPP 696_ GPTGA 701_ KGLRG 706_ IPGFA 711_ GADGG 716_ PGPRG 721_ LPGDA 726_ GREGF 731_ PGPPG 736_ FIGPR 741_ GSKGA 746_ VGLPG 751_ PDGSP 756_ GPIGL 761_ PGPDG 766_ PPGER 771_ GLPGE 776_ VLGAQ 781_ PGPRG 786_ DAGVP 791_ GQPGL 796_ KGLPG 801_ DRGPP 806_ GFRGS 811_ QGMPG 816_ MPGLK 821_ GQPGL 826_ PGPSG 831_ QPGLY 836_ GPPGL 841_ HGFPG 846_ APGQE 851_ GPLGL 856_ PGIPG 861_ REGLP 866_ GDRGD 871_ PGDTG 876_ APGPV 881_ GMKGL 886_ SGDRG 891_ DAGFT 896_ GEQGH 901_ PGSPG 906_ FKGID 911_ GMPGT 916_ PGLKG 921_ DRGSP 926_ GMDGF 931_ QGMPG 936_ LKGRP 941_ GFPGS 946_ KGEAG 951_ FFGIP 956_ GLKGL 961_ AGEPG 966_ FKGSR 971_ GDPGP 976_ PGPPP 981_ VILPG 986_ MKDIK 991_ GEKGD 996_ EGPMG 1001_ LKGYL 1006_ GAKGI 1011_ QGMPG 1016_ IPGLS 1021_ GIPGL 1026_ PGRPG 1031_ HIKGV 1036_ KGDIG 1041_ VPGIP 1046_ GLPGF 1051_ PGVAG 1056_ PPGIT 1061_ GFPGF 1066_ IGSRG 1071_ DKGAP 1076_ GRAGL 1081_ YGEIG 1086_ ATGDF 1091_ GDIGD 1096_ TINLP 1101_ GRPGL 1106_ KGERG 1111_ TTGIP 1116_ GLKGF 1121_ FGEKG 1126_ TEGDI 1131_ GFPGI 1136_ TGVTG 1141_ VQGPP 1146_ GLKGQ 1151_ TGFPG 1156_ LTGPP 1161_ GSQGE 1166_ LGRIG 1171_ LPGGK 1176_ GDDGW 1181_ PGAPG 1186_ LPGFP 1191_ GLRGI 1196_ RGLHG 1201_ LPGTK 1206_ GFPGS 1211_ PGSDI 1216_ HGDPG 1221_ FPGPP 1226_ GERGD 1231_ PGEAN 1236_ TLPGP 1241_ VGVPG 1246_ QKGDQ 1251_ GAPGE 1256_ RGPPG 1261_ SPGLQ 1266_ GFPGI 1271_ TPPSN 1276_ ISGAP 1281_ GDKGA 1286_ PGIFG 1291_ LKGYR 1296_ GPPGP 1301_ PGSAA 1306_ LPGSK 1311_ GDTGN 1316_ PGAPG 1321_ TPGTK 1326_ GWAGD 1331_ SGPQG 1336_ RPGVF 1341_ GLPGE 1346_ KGPRG 1351_ EQGFM 1356_ GNTGP 1361_ TGAVG 1366_ DRGPK 1371_ GPKGD 1376_ PGFPG 1381_ APGTV 1386_ GAPGI 1391_ AGIPQ 1396_ KIAVQ 1401_ PGTVG 1406_ PQGRR 1411_ GPPGA 1416_ PGEMG 1421_ PQGPP 1426_ GEPGF 1431_ RGAPG 1436_ KAGPQ 1441_ GRGGV 1446_ SAVPG 1451_ FRGDE 1456_ GPIGH 1461_ QGPIG 1466_ QEGAP 1471_ GRPGS 1476_ PGLPG 1481_ MPGRS 1486_ VSIGY 1491_ LLVKH 1496_ SQTDQ 1501_ EPMCP 1506_ VGMNK 1511_ LWSGY 1516_ SLLYF 1521_ EGQEK 1526_ AHNQD 1531_ LGLAG 1536_ SCLAR 1541_ FSTMP 1546_ FLYCN 1551_ PGDVC 1556_ YYASR 1561_ NDKSY 1566_ WLSTT 1571_ APLPM 1576_ MPVAE 1581_ DEIKP 1586_ YISRC 1591_ SVCEA 1596_ PAIAI 1601_ AVHSQ 1606_ DVSIP 1611_ HCPAG 1616_ WRSLW 1621_ IGYSF 1626_ LMHTA 1631_ AGDEG 1636_ GGQSL 1641_ VSPGS 1646_ CLEDF 1651_ RATPF 1656_ IECNG 1661_ GRGTC 1666_ HYYAN 1671_ KYSFW 1676_ LTTIP 1681_ EQSFQ 1686_ GSPSA 1691_ DTLKA 1696_ GLIRT 1701_ HISRC 1706_QVCMK
1: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen
2: Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins