Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)
1_MAAAA 6_ ASLRG 11_ VVLGP 16_ RGAGL 21_ PGARA 26_ RGLLC 31_ SARPG 36_ QLPLR 41_ TPQAV 46_ ALSSK 51_ SGLSR 56_ GRKVM 61_ LSALG 66_ MLAAG 71_ GAGLA 76_ MALHS 81_ AVSAS 86_ DLELH 91_ PPSYP 96_ WSHRG 101_ LLSSL 106_ DHTSI 111_ RRGFQ 116_ VYKQV 121_ CASCH 126_ SMDFV 131_ AYRHL 136_ VGVCY 141_ TEDEA 146_ KELAA 151_ EVEVQ 156_ DGPNE 161_ DGEMF 166_ MRPGK 171_ LFDYF 176_ PKPYP 181_ NSEAA 186_ RAANN 191_ GALPP 196_ DLSYI 201_ VRARH 206_ GGEDY 211_ VFSLL 216_ TGYCE 221_ PPTGV 226_ SLREG 231_ LYFNP 236_ YFPGQ 241_ AIAMA 246_ PPIYT 251_ DVLEF 256_ DDGTP 261_ ATMSQ 266_ IAKDV 271_ CTFLR 276_ WASEP 281_ EHDHR 286_ KRMGL 291_ KMLMM 296_ MALLV 301_ PLVYT 306_ IKRHK 311_ WSVLK 316_SRKLA
1: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c