Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
1_MTMYL 6_ WLKLL 11_ AFGFA 16_ FLDTE 21_ VFVTG 26_ QSPTP 31_ SPTGL 36_ TTAKM 41_ PSVPL 46_ SSDPL 51_ PTHTT 56_ AFSPA 61_ STFER 66_ ENDFS 71_ ETTTS 76_ LSPDN 81_ TSTQV 86_ SPDSL 91_ DNASA 96_ FNTTG 101_ VSSVQ 106_ TPHLP 111_ THADS 116_ QTPSA 121_ GTDTQ 126_ TFSGS 131_ AANAK 136_ LNPTP 141_ GSNAI 146_ SDVPG 151_ ERSTA 156_ STFPT 161_ DPVSP 166_ LTTTL 171_ SLAHH 176_ SSAAL 181_ PARTS 186_ NTTIT 191_ ANTSD 196_ AYLNA 201_ SETTT 206_ LSPSG 211_ SAVIS 216_ TTTIA 221_ TTPSK 226_ PTCDE 231_ KYANI 236_ TVDYL 241_ YNKET 246_ KLFTA 251_ KLNVN 256_ ENVEC 261_ GNNTC 266_ TNNEV 271_ HNLTE 276_ CKNAS 281_ VSISH 286_ NSCTA 291_ PDKTL 296_ ILDVP 301_ PGVEK 306_ FQLHD 311_ CTQVE 316_ KADTT 321_ ICLKW 326_ KNIET 331_ FTCDT 336_ QNITY 341_ RFQCG 346_ NMIFD 351_ NKEIK 356_ LENLE 361_ PEHEY 366_ KCDSE 371_ ILYNN 376_ HKFTN 381_ ASKII 386_ KTDFG 391_ SPGEP 396_ QIIFC 401_ RSEAA 406_ HQGVI 411_ TWNPP 416_ QRSFH 421_ NFTLC 426_ YIKET 431_ EKDCL 436_ NLDKN 441_ LIKYD 446_ LQNLK 451_ PYTKY 456_ VLSLH 461_ AYIIA 466_ KVQRN 471_ GSAAM 476_ CHFTT 481_ KSAPP 486_ SQVWN 491_ MTVSM 496_ TSDNS 501_ MHVKC 506_ RPPRD 511_ RNGPH 516_ ERYHL 521_ EVEAG 526_ NTLVR 531_ NESHK 536_ NCDFR 541_ VKDLQ 546_ YSTDY 551_ TFKAY 556_ FHNGD 561_ YPGEP 566_ FILHH 571_ STSYN 576_ SKALI 581_ AFLAF 586_ LIIVT 591_ SIALL 596_ VVLYK 601_ IYDLH 606_ KKRSC 611_ NLDEQ 616_ QELVE 621_ RDDEK 626_ QLMNV 631_ EPIHA 636_ DILLE 641_ TYKRK 646_ IADEG 651_ RLFLA 656_ EFQSI 661_ PRVFS 666_ KFPIK 671_ EARKP 676_ FNQNK 681_ NRYVD 686_ ILPYD 691_ YNRVE 696_ LSEIN 701_ GDAGS 706_ NYINA 711_ SYIDG 716_ FKEPR 721_ KYIAA 726_ QGPRD 731_ ETVDD 736_ FWRMI 741_ WEQKA 746_ TVIVM 751_ VTRCE 756_ EGNRN 761_ KCAEY 766_ WPSME 771_ EGTRA 776_ FGDVV 781_ VKINQ 786_ HKRCP 791_ DYIIQ 796_ KLNIV 801_ NKKEK 806_ ATGRE 811_ VTHIQ 816_ FTSWP 821_ DHGVP 826_ EDPHL 831_ LLKLR 836_ RRVNA 841_ FSNFF 846_ SGPIV 851_ VHCSA 856_ GVGRT 861_ GTYIG 866_ IDAML 871_ EGLEA 876_ ENKVD 881_ VYGYV 886_ VKLRR 891_ QRCLM 896_ VQVEA 901_ QYILI 906_ HQALV 911_ EYNQF 916_ GETEV 921_ NLSEL 926_ HPYLH 931_ NMKKR 936_ DPPSE 941_ PSPLE 946_ AEFQR 951_ LPSYR 956_ SWRTQ 961_ HIGNQ 966_ EENKS 971_ KNRNS 976_ NVIPY 981_ DYNRV 986_ PLKHE 991_ LEMSK 996_ ESEHD 1001_ SDESS 1006_ DDDSD 1011_ SEEPS 1016_ KYINA 1021_ SFIMS 1026_ YWKPE 1031_ VMIAA 1036_ QGPLK 1041_ ETIGD 1046_ FWQMI 1051_ FQRKV 1056_ KVIVM 1061_ LTELK 1066_ HGDQE 1071_ ICAQY 1076_ WGEGK 1081_ QTYGD 1086_ IEVDL 1091_ KDTDK 1096_ SSTYT 1101_ LRVFE 1106_ LRHSK 1111_ RKDSR 1116_ TVYQY 1121_ QYTNW 1126_ SVEQL 1131_ PAEPK 1136_ ELISM 1141_ IQVVK 1146_ QKLPQ 1151_ KNSSE 1156_ GNKHH 1161_ KSTPL 1166_ LIHCR 1171_ DGSQQ 1176_ TGIFC 1181_ ALLNL 1186_ LESAE 1191_ TEEVV 1196_ DIFQV 1201_ VKALR 1206_ KARPG 1211_ MVSTF 1216_ EQYQF 1221_ LYDVI 1226_ ASTYP 1231_ AQNGQ 1236_ VKKNN 1241_ HQEDK 1246_ IEFDN 1251_ EVDKV 1256_ KQDAN 1261_ CVNPL 1266_ GAPEK 1271_ LPEAK 1276_ EQAEG 1281_ SEPTS 1286_ GTEGP 1291_ EHSVN 1296_ GPASP 1301_ALNQG
1: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity
2: (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation