Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
1_MKAPA 6_ VLAPG 11_ ILVLL 16_ FTLVQ 21_ RSNGE 26_ CKEAL 31_ AKSEM 36_ NVNMK 41_ YQLPN 46_ FTAET 51_ PIQNV 56_ ILHEH 61_ HIFLG 66_ ATNYI 71_ YVLNE 76_ EDLQK 81_ VAEYK 86_ TGPVL 91_ EHPDC 96_ FPCQD 101_ CSSKA 106_ NLSGG 111_ VWKDN 116_ INMAL 121_ VVDTY 126_ YDDQL 131_ ISCGS 136_ VNRGT 141_ CQRHV 146_ FPHNH 151_ TADIQ 156_ SEVHC 161_ IFSPQ 166_ IEEPS 171_ QCPDC 176_ VVSAL 181_ GAKVL 186_ SSVKD 191_ RFINF 196_ FVGNT 201_ INSSY 206_ FPDHP 211_ LHSIS 216_ VRRLK 221_ ETKDG 226_ FMFLT 231_ DQSYI 236_ DVLPE 241_ FRDSY 246_ PIKYV 251_ HAFES 256_ NNFIY 261_ FLTVQ 266_ RETLD 271_ AQTFH 276_ TRIIR 281_ FCSIN 286_ SGLHS 291_ YMEMP 296_ LECIL 301_ TEKRK 306_ KRSTK 311_ KEVFN 316_ ILQAA 321_ YVSKP 326_ GAQLA 331_ RQIGA 336_ SLNDD 341_ ILFGV 346_ FAQSK 351_ PDSAE 356_ PMDRS 361_ AMCAF 366_ PIKYV 371_ NDFFN 376_ KIVNK 381_ NNVRC 386_ LQHFY 391_ GPNHE 396_ HCFNR 401_ TLLRN 406_ SSGCE 411_ ARRDE 416_ YRTEF 421_ TTALQ 426_ RVDLF 431_ MGQFS 436_ EVLLT 441_ SISTF 446_ IKGDL 451_ TIANL 456_ GTSEG 461_ RFMQV 466_ VVSRS 471_ GPSTP 476_ HVNFL 481_ LDSHP 486_ VSPEV 491_ IVEHT 496_ LNQNG 501_ YTLVI 506_ TGKKI 511_ TKIPL 516_ NGLGC 521_ RHFQS 526_ CSQCL 531_ SAPPF 536_ VQCGW 541_ CHDKC 546_ VRSEE 551_ CLSGT 556_ WTQQI 561_ CLPAI 566_ YKVFP 571_ NSAPL 576_ EGGTR 581_ LTICG 586_ WDFGF 591_ RRNNK 596_ FDLKK 601_ TRVLL 606_ GNESC 611_ TLTLS 616_ ESTMN 621_ TLKCT 626_ VGPAM 631_ NKHFN 636_ MSIII 641_ SNGHG 646_ TTQYS 651_ TFSYV 656_ DPVIT 661_ SISPK 666_ YGPMA 671_ GGTLL 676_ TLTGN 681_ YLNSG 686_ NSRHI 691_ SIGGK 696_ TCTLK 701_ SVSNS 706_ ILECY 711_ TPAQT 716_ ISTEF 721_ AVKLK 726_ IDLAN 731_ RETSI 736_ FSYRE 741_ DPIVY 746_ EIHPT 751_ KSFIS 756_ GGSTI 761_ TGVGK 766_ NLNSV 771_ SVPRM 776_ VINVH 781_ EAGRN 786_ FTVAC 791_ QHRSN 796_ SEIIC 801_ CTTPS 806_ LQQLN 811_ LQLPL 816_ KTKAF 821_ FMLDG 826_ ILSKY 831_ FDLIY 836_ VHNPV 841_ FKPFE 846_ KPVMI 851_ SMGNE 856_ NVLEI 861_ KGNDI 866_ DPEAV 871_ KGEVL 876_ KVGNK 881_ SCENI 886_ HLHSE 891_ AVLCT 896_ VPNDL 901_ LKLNS 906_ ELNIE 911_ WKQAI 916_ SSTVL 921_ GKVIV 926_ QPDQN 931_ FTGLI 936_ AGVVS 941_ ISTAL 946_ LLLLG 951_ FFLWL 956_ KKRKQ 961_ IKDLG 966_ SELVR 971_ YDARV 976_ HTPHL 981_ DRLVS 986_ ARSVS 991_ PTTEM 996_ VSNES 1001_ VDYRA 1006_ TFPED 1011_ QFPNS 1016_ SQNGS 1021_ CRQVQ 1026_ YPLTD 1031_ MSPIL 1036_ TSGDS 1041_ DISSP 1046_ LLQNT 1051_ VHIDL 1056_ SALNP 1061_ ELVQA 1066_ VQHVV 1071_ IGPSS 1076_ LIVHF 1081_ NEVIG 1086_ RGHFG 1091_ CVYHG 1096_ TLLDN 1101_ DGKKI 1106_ HCAVK 1111_ SLNRI 1116_ TDIGE 1121_ VSQFL 1126_ TEGII 1131_ MKDFS 1136_ HPNVL 1141_ SLLGI 1146_ CLRSE 1151_ GSPLV 1156_ VLPYM 1161_ KHGDL 1166_ RNFIR 1171_ NETHN 1176_ PTVKD 1181_ LIGFG 1186_ LQVAK 1191_ GMKYL 1196_ ASKKF 1201_ VHRDL 1206_ AARNC 1211_ MLDEK 1216_ FTVKV 1221_ ADFGL 1226_ ARDMY 1231_ DKEYY 1236_ SVHNK 1241_ TGAKL 1246_ PVKWM 1251_ ALESL 1256_ QTQKF 1261_ TTKSD 1266_ VWSFG 1271_ VLLWE 1276_ LMTRG 1281_ APPYP 1286_ DVNTF 1291_ DITVY 1296_ LLQGR 1301_ RLLQP 1306_ EYCPD 1311_ PLYEV 1316_ MLKCW 1321_ HPKAE 1326_ MRPSF 1331_ SELVS 1336_ RISAI 1341_ FSTFI 1346_ GEHYV 1351_ HVNAT 1356_ YVNVK 1361_ CVAPY 1366_ PSLLS 1371_ SEDNA 1376_ DDEVD 1381_TRPAS
1: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity)
2: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells