Complement factor H (H factor 1)
1_MRLLA 6_ KIICL 11_ MLWAI 16_ CVAED 21_ CNELP 26_ PRRNT 31_ EILTG 36_ SWSDQ 41_ TYPEG 46_ TQAIY 51_ KCRPG 56_ YRSLG 61_ NVIMV 66_ CRKGE 71_ WVALN 76_ PLRKC 81_ QKRPC 86_ GHPGD 91_ TPFGT 96_ FTLTG 101_ GNVFE 106_ YGVKA 111_ VYTCN 116_ EGYQL 121_ LGEIN 126_ YRECD 131_ TDGWT 136_ NDIPI 141_ CEVVK 146_ CLPVT 151_ APENG 156_ KIVSS 161_ AMEPD 166_ REYHF 171_ GQAVR 176_ FVCNS 181_ GYKIE 186_ GDEEM 191_ HCSDD 196_ GFWSK 201_ EKPKC 206_ VEISC 211_ KSPDV 216_ INGSP 221_ ISQKI 226_ IYKEN 231_ ERFQY 236_ KCNMG 241_ YEYSE 246_ RGDAV 251_ CTESG 256_ WRPLP 261_ SCEEK 266_ SCDNP 271_ YIPNG 276_ DYSPL 281_ RIKHR 286_ TGDEI 291_ TYQCR 296_ NGFYP 301_ ATRGN 306_ TAKCT 311_ STGWI 316_ PAPRC 321_ TLKPC 326_ DYPDI 331_ KHGGL 336_ YHENM 341_ RRPYF 346_ PVAVG 351_ KYYSY 356_ YCDEH 361_ FETPS 366_ GSYWD 371_ HIHCT 376_ QDGWS 381_ PAVPC 386_ LRKCY 391_ FPYLE 396_ NGYNQ 401_ NYGRK 406_ FVQGK 411_ SIDVA 416_ CHPGY 421_ ALPKA 426_ QTTVT 431_ CMENG 436_ WSPTP 441_ RCIRV 446_ KTCSK 451_ SSIDI 456_ ENGFI 461_ SESQY 466_ TYALK 471_ EKAKY 476_ QCKLG 481_ YVTAD 486_ GETSG 491_ SITCG 496_ KDGWS 501_ AQPTC 506_ IKSCD 511_ IPVFM 516_ NARTK 521_ NDFTW 526_ FKLND 531_ TLDYE 536_ CHDGY 541_ ESNTG 546_ STTGS 551_ IVCGY 556_ NGWSD 561_ LPICY 566_ ERECE 571_ LPKID 576_ VHLVP 581_ DRKKD 586_ QYKVG 591_ EVLKF 596_ SCKPG 601_ FTIVG 606_ PNSVQ 611_ CYHFG 616_ LSPDL 621_ PICKE 626_ QVQSC 631_ GPPPE 636_ LLNGN 641_ VKEKT 646_ KEEYG 651_ HSEVV 656_ EYYCN 661_ PRFLM 666_ KGPNK 671_ IQCVD 676_ GEWTT 681_ LPVCI 686_ VEEST 691_ CGDIP 696_ ELEHG 701_ WAQLS 706_ SPPYY 711_ YGDSV 716_ EFNCS 721_ ESFTM 726_ IGHRS 731_ ITCIH 736_ GVWTQ 741_ LPQCV 746_ AIDKL 751_ KKCKS 756_ SNLII 761_ LEEHL 766_ KNKKE 771_ FDHNS 776_ NIRYR 781_ CRGKE 786_ GWIHT 791_ VCING 796_ RWDPE 801_ VNCSM 806_ AQIQL 811_ CPPPP 816_ QIPNS 821_ HNMTT 826_ TLNYR 831_ DGEKV 836_ SVLCQ 841_ ENYLI 846_ QEGEE 851_ ITCKD 856_ GRWQS 861_ IPLCV 866_ EKIPC 871_ SQPPQ 876_ IEHGT 881_ INSSR 886_ SSQES 891_ YAHGT 896_ KLSYT 901_ CEGGF 906_ RISEE 911_ NETTC 916_ YMGKW 921_ SSPPQ 926_ CEGLP 931_ CKSPP 936_ EISHG 941_ VVAHM 946_ SDSYQ 951_ YGEEV 956_ TYKCF 961_ EGFGI 966_ DGPAI 971_ AKCLG 976_ EKWSH 981_ PPSCI 986_ KTDCL 991_ SLPSF 996_ ENAIP 1001_ MGEKK 1006_ DVYKA 1011_ GEQVT 1016_ YTCAT 1021_ YYKMD 1026_ GASNV 1031_ TCINS 1036_ RWTGR 1041_ PTCRD 1046_ TSCVN 1051_ PPTVQ 1056_ NAYIV 1061_ SRQMS 1066_ KYPSG 1071_ ERVRY 1076_ QCRSP 1081_ YEMFG 1086_ DEEVM 1091_ CLNGN 1096_ WTEPP 1101_ QCKDS 1106_ TGKCG 1111_ PPPPI 1116_ DNGDI 1121_ TSFPL 1126_ SVYAP 1131_ ASSVE 1136_ YQCQN 1141_ LYQLE 1146_ GNKRI 1151_ TCRNG 1156_ QWSEP 1161_ PKCLH 1166_ PCVIS 1171_ REIME 1176_ NYNIA 1181_ LRWTA 1186_ KQKLY 1191_ SRTGE 1196_ SVEFV 1201_ CKRGY 1206_ RLSSR 1211_ SHTLR 1216_ TTCWD 1221_ GKLEY 1226_PTCAK
1: Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed:21285368, PubMed:21317894, PubMed:25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed:19503104, PubMed:21317894, PubMed:26700768). As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed:18252712, PubMed:23332154, PubMed:28671664). In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed (PubMed:20008295, PubMed:9558116)
2: (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination