U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
1_MTQFL 6_ PPNLL 11_ ALFAP 16_ RDPIP 21_ YLPPL 26_ EKLPH 31_ EKHHN 36_ QPYCG 41_ IAPYI 46_ REFED 51_ PRDAP 56_ PPTRA 61_ ETREE 66_ RMERK 71_ RREKI 76_ ERRQQ 81_ EVETE 86_ LKMWD 91_ PHNDP 96_ NAQGD 101_ AFKTL 106_ FVARV 111_ NYDTT 116_ ESKLR 121_ REFEV 126_ YGPIK 131_ RIHMV 136_ YSKRS 141_ GKPRG 146_ YAFIE 151_ YEHER 156_ DMHSA 161_ YKHAD 166_ GKKID 171_ GRRVL 176_ VDVER 181_ GRTVK 186_ GWRPR 191_ RLGGG 196_ LGGTR 201_ RGGAD 206_ VNIRH 211_ SGRDD 216_ TSRYD 221_ ERPGP 226_ SPLPH 231_ RDRDR 236_ DRERE 241_ RRERS 246_ RERDK 251_ ERERR 256_ RSRSR 261_ DRRRR 266_ SRSRD 271_ KEERR 276_ RSRER 281_ SKDKD 286_ RDRKR 291_ RSSRS 296_ RERAR 301_ RERER 306_ KEELR 311_ GGGGD 316_ MAEPS 321_ EAGDA 326_ PPDDG 331_ PPGEL 336_ GPDGP 341_ DGPEE 346_ KGRDR 351_ DRERR 356_ RSHRS 361_ ERERR 366_ RDRDR 371_ DRDRD 376_ REHKR 381_ GERGS 386_ ERGRD 391_ EARGG 396_ GGGQD 401_ NGLEG 406_ LGNDS 411_ RDMYM 416_ ESEGG 421_ DGYLA 426_ PENGY 431_LMEAA
1: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158)
2: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA
3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA