Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
1_MGGRS 6_ SCEDP 11_ GCPRD 16_ EERAP 21_ RMGCM 26_ KSKFL 31_ QVGGN 36_ TFSKT 41_ ETSAS 46_ PHCPV 51_ YVPDP 56_ TSTIK 61_ PGPNS 66_ HNSNT 71_ PGIRE 76_ AGSED 81_ IIVVA 86_ LYDYE 91_ AIHHE 96_ DLSFQ 101_ KGDQM 106_ VVLEE 111_ SGEWW 116_ KARSL 121_ ATRKE 126_ GYIPS 131_ NYVAR 136_ VDSLE 141_ TEEWF 146_ FKGIS 151_ RKDAE 156_ RQLLA 161_ PGNML 166_ GSFMI 171_ RDSET 176_ TKGSY 181_ SLSVR 186_ DYDPR 191_ QGDTV 196_ KHYKI 201_ RTLDN 206_ GGFYI 211_ SPRST 216_ FSTLQ 221_ ELVDH 226_ YKKGN 231_ DGLCQ 236_ KLSVP 241_ CMSSK 246_ PQKPW 251_ EKDAW 256_ EIPRE 261_ SLKLE 266_ KKLGA 271_ GQFGE 276_ VWMAT 281_ YNKHT 286_ KVAVK 291_ TMKPG 296_ SMSVE 301_ AFLAE 306_ ANVMK 311_ TLQHD 316_ KLVKL 321_ HAVVT 326_ KEPIY 331_ IITEF 336_ MAKGS 341_ LLDFL 346_ KSDEG 351_ SKQPL 356_ PKLID 361_ FSAQI 366_ AEGMA 371_ FIEQR 376_ NYIHR 381_ DLRAA 386_ NILVS 391_ ASLVC 396_ KIADF 401_ GLARV 406_ IEDNE 411_ YTARE 416_ GAKFP 421_ IKWTA 426_ PEAIN 431_ FGSFT 436_ IKSDV 441_ WSFGI 446_ LLMEI 451_ VTYGR 456_ IPYPG 461_ MSNPE 466_ VIRAL 471_ ERGYR 476_ MPRPE 481_ NCPEE 486_ LYNIM 491_ MRCWK 496_ NRPEE 501_ RPTFE 506_ YIQSV 511_ LDDFY 516_ TATES 521_QYQQQ
1: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS