Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]
1_MGSRT 6_ PESPL 11_ HAVQL 16_ RWGPR 21_ RRPPL 26_ LPLLL 31_ LLLPP 36_ PPRVG 41_ GFNLD 46_ AEAPA 51_ VLSGP 56_ PGSFF 61_ GFSVE 66_ FYRPG 71_ TDGVS 76_ VLVGA 81_ PKANT 86_ SQPGV 91_ LQGGA 96_ VYLCP 101_ WGASP 106_ TQCTP 111_ IEFDS 116_ KGSRL 121_ LESSL 126_ SSSEG 131_ EEPVE 136_ YKSLQ 141_ WFGAT 146_ VRAHG 151_ SSILA 156_ CAPLY 161_ SWRTE 166_ KEPLS 171_ DPVGT 176_ CYLST 181_ DNFTR 186_ ILEYA 191_ PCRSD 196_ FSWAA 201_ GQGYC 206_ QGGFS 211_ AEFTK 216_ TGRVV 221_ LGGPG 226_ SYFWQ 231_ GQILS 236_ ATQEQ 241_ IAESY 246_ YPEYL 251_ INLVQ 256_ GQLQT 261_ RQASS 266_ IYDDS 271_ YLGYS 276_ VAVGE 281_ FSGDD 286_ TEDFV 291_ AGVPK 296_ GNLTY 301_ GYVTI 306_ LNGSD 311_ IRSLY 316_ NFSGE 321_ QMASY 326_ FGYAV 331_ AATDV 336_ NGDGL 341_ DDLLV 346_ GAPLL 351_ MDRTP 356_ DGRPQ 361_ EVGRV 366_ YVYLQ 371_ HPAGI 376_ EPTPT 381_ LTLTG 386_ HDEFG 391_ RFGSS 396_ LTPLG 401_ DLDQD 406_ GYNDV 411_ AIGAP 416_ FGGET 421_ QQGVV 426_ FVFPG 431_ GPGGL 436_ GSKPS 441_ QVLQP 446_ LWAAS 451_ HTPDF 456_ FGSAL 461_ RGGRD 466_ LDGNG 471_ YPDLI 476_ VGSFG 481_ VDKAV 486_ VYRGR 491_ PIVSA 496_ SASLT 501_ IFPAM 506_ FNPEE 511_ RSCSL 516_ EGNPV 521_ ACINL 526_ SFCLN 531_ ASGKH 536_ VADSI 541_ GFTVE 546_ LQLDW 551_ QKQKG 556_ GVRRA 561_ LFLAS 566_ RQATL 571_ TQTLL 576_ IQNGA 581_ REDCR 586_ EMKIY 591_ LRNES 596_ EFRDK 601_ LSPIH 606_ IALNF 611_ SLDPQ 616_ APVDS 621_ HGLRP 626_ ALHYQ 631_ SKSRI 636_ EDKAQ 641_ ILLDC 646_ GEDNI 651_ CVPDL 656_ QLEVF 661_ GEQNH 666_ VYLGD 671_ KNALN 676_ LTFHA 681_ QNVGE 686_ GGAYE 691_ AELRV 696_ TAPPE 701_ AEYSG 706_ LVRHP 711_ GNFSS 716_ LSCDY 721_ FAVNQ 726_ SRLLV 731_ CDLGN 736_ PMKAG 741_ ASLWG 746_ GLRFT 751_ VPHLR 756_ DTKKT 761_ IQFDF 766_ QILSK 771_ NLNNS 776_ QSDVV 781_ SFRLS 786_ VEAQA 791_ QVTLN 796_ GVSKP 801_ EAVLF 806_ PVSDW 811_ HPRDQ 816_ PQKEE 821_ DLGPA 826_ VHHVY 831_ ELINQ 836_ GPSSI 841_ SQGVL 846_ ELSCP 851_ QALEG 856_ QQLLY 861_ VTRVT 866_ GLNCT 871_ TNHPI 876_ NPKGL 881_ ELDPE 886_ GSLHH 891_ QQKRE 896_ APSRS 901_ SASSG 906_ PQILK 911_ CPEAE 916_ CFRLR 921_ CELGP 926_ LHQQE 931_ SQSLQ 936_ LHFRV 941_ WAKTF 946_ LQREH 951_ QPFSL 956_ QCEAV 961_ YKALK 966_ MPYRI 971_ LPRQL 976_ PQKER 981_ QVATA 986_ VQWTK 991_ AEGSY 996_ GVPLW 1001_ IIILA 1006_ ILFGL 1011_ LLLGL 1016_ LIYIL 1021_ YKLGF 1026_ FKRSL 1031_ PYGTA 1036_ MEKAQ 1041_LKPPA
1: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973)
2: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus
3: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19
4: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions