Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)
1_MALIP 6_ DLAME 11_ TWLLL 16_ AVSLV 21_ LLYLY 26_ GTHSH 31_ GLFKK 36_ LGIPG 41_ PTPLP 46_ FLGNI 51_ LSYHK 56_ GFCMF 61_ DMECH 66_ KKYGK 71_ VWGFY 76_ DGQQP 81_ VLAIT 86_ DPDMI 91_ KTVLV 96_ KECYS 101_ VFTNR 106_ RPFGP 111_ VGFMK 116_ SAISI 121_ AEDEE 126_ WKRLR 131_ SLLSP 136_ TFTSG 141_ KLKEM 146_ VPIIA 151_ QYGDV 156_ LVRNL 161_ RREAE 166_ TGKPV 171_ TLKDV 176_ FGAYS 181_ MDVIT 186_ STSFG 191_ VNIDS 196_ LNNPQ 201_ DPFVE 206_ NTKKL 211_ LRFDF 216_ LDPFF 221_ LSITV 226_ FPFLI 231_ PILEV 236_ LNICV 241_ FPREV 246_ TNFLR 251_ KSVKR 256_ MKESR 261_ LEDTQ 266_ KHRVD 271_ FLQLM 276_ IDSQN 281_ SKETE 286_ SHKAL 291_ SDLEL 296_ VAQSI 301_ IFIFA 306_ GYETT 311_ SSVLS 316_ FIMYE 321_ LATHP 326_ DVQQK 331_ LQEEI 336_ DAVLP 341_ NKAPP 346_ TYDTV 351_ LQMEY 356_ LDMVV 361_ NETLR 366_ LFPIA 371_ MRLER 376_ VCKKD 381_ VEING 386_ MFIPK 391_ GVVVM 396_ IPSYA 401_ LHRDP 406_ KYWTE 411_ PEKFL 416_ PERFS 421_ KKNKD 426_ NIDPY 431_ IYTPF 436_ GSGPR 441_ NCIGM 446_ RFALM 451_ NMKLA 456_ LIRVL 461_ QNFSF 466_ KPCKE 471_ TQIPL 476_ KLSLG 481_ GLLQP 486_ EKPVV 491_ LKVES 496_RDGTV
1: A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981)