Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Cytochrome P450-C21B)
1_MLLLG 6_ LLLLP 11_ LLAGA 16_ RLLWN 21_ WWKLR 26_ SLHLP 31_ PLAPG 36_ FLHLL 41_ QPDLP 46_ IYLLG 51_ LTQKF 56_ GPIYR 61_ LHLGL 66_ QDVVV 71_ LNSKR 76_ TIEEA 81_ MVKKW 86_ ADFAG 91_ RPEPL 96_ TYKLV 101_ SKNYP 106_ DLSLG 111_ DYSLL 116_ WKAHK 121_ KLTRS 126_ ALLLG 131_ IRDSM 136_ EPVVE 141_ QLTQE 146_ FCERM 151_ RAQPG 156_ TPVAI 161_ EEEFS 166_ LLTCS 171_ IICYL 176_ TFGDK 181_ IKDDN 186_ LMPAY 191_ YKCIQ 196_ EVLKT 201_ WSHWS 206_ IQIVD 211_ VIPFL 216_ RFFPN 221_ PGLRR 226_ LKQAI 231_ EKRDH 236_ IVEMQ 241_ LRQHK 246_ ESLVA 251_ GQWRD 256_ MMDYM 261_ LQGVA 266_ QPSME 271_ EGSGQ 276_ LLEGH 281_ VHMAA 286_ VDLLI 291_ GGTET 296_ TANTL 301_ SWAVV 306_ FLLHH 311_ PEIQQ 316_ RLQEE 321_ LDHEL 326_ GPGAS 331_ SSRVP 336_ YKDRA 341_ RLPLL 346_ NATIA 351_ EVLRL 356_ RPVVP 361_ LALPH 366_ RTTRP 371_ SSISG 376_ YDIPE 381_ GTVII 386_ PNLQG 391_ AHLDE 396_ TVWER 401_ PHEFW 406_ PDRFL 411_ EPGKN 416_ SRALA 421_ FGCGA 426_ RVCLG 431_ EPLAR 436_ LELFV 441_ VLTRL 446_ LQAFT 451_ LLPSG 456_ DALPS 461_ LQPLP 466_ HCSVI 471_ LKMQP 476_ FQVRL 481_ QPRGM 486_GAHSP
1: A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:10602386, PubMed:16984992, PubMed:22014889, PubMed:25855791, PubMed:27721825). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791)