Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor)
1_MSRLP 6_ VLLLL 11_ QLLVR 16_ PGLQA 21_ PMTQT 26_ TPLKT 31_ SWVNC 36_ SNMID 41_ EIITH 46_ LKQPP 51_ LPLLD 56_ FNNLN 61_ GEDQD 66_ ILMEN 71_ NLRRP 76_ NLEAF 81_ NRAVK 86_ SLQNA 91_ SAIES 96_ ILKNL 101_ LPCLP 106_ LATAA 111_ PTRHP 116_ IHIKD 121_ GDWNE 126_ FRRKL 131_ TFYLK 136_ TLENA 141_ QAQQT 146_TLSLA
1: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442). Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated (PubMed:10779277, PubMed:32889153). In addition, plays an important role in neural cell proliferation and survival (PubMed:23226269). Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation (PubMed:12816992). Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (PubMed:29374162). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (PubMed:27862234)