Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
1_MVSQA 6_ LRLLC 11_ LLLGL 16_ QGCLA 21_ AGGVA 26_ KASGG 31_ ETRDM 36_ PWKPG 41_ PHRVF 46_ VTQEE 51_ AHGVL 56_ HRRRR 61_ ANAFL 66_ EELRP 71_ GSLER 76_ ECKEE 81_ QCSFE 86_ EAREI 91_ FKDAE 96_ RTKLF 101_ WISYS 106_ DGDQC 111_ ASSPC 116_ QNGGS 121_ CKDQL 126_ QSYIC 131_ FCLPA 136_ FEGRN 141_ CETHK 146_ DDQLI 151_ CVNEN 156_ GGCEQ 161_ YCSDH 166_ TGTKR 171_ SCRCH 176_ EGYSL 181_ LADGV 186_ SCTPT 191_ VEYPC 196_ GKIPI 201_ LEKRN 206_ ASKPQ 211_ GRIVG 216_ GKVCP 221_ KGECP 226_ WQVLL 231_ LVNGA 236_ QLCGG 241_ TLINT 246_ IWVVS 251_ AAHCF 256_ DKIKN 261_ WRNLI 266_ AVLGE 271_ HDLSE 276_ HDGDE 281_ QSRRV 286_ AQVII 291_ PSTYV 296_ PGTTN 301_ HDIAL 306_ LRLHQ 311_ PVVLT 316_ DHVVP 321_ LCLPE 326_ RTFSE 331_ RTLAF 336_ VRFSL 341_ VSGWG 346_ QLLDR 351_ GATAL 356_ ELMVL 361_ NVPRL 366_ MTQDC 371_ LQQSR 376_ KVGDS 381_ PNITE 386_ YMFCA 391_ GYSDG 396_ SKDSC 401_ KGDSG 406_ GPHAT 411_ HYRGT 416_ WYLTG 421_ IVSWG 426_ QGCAT 431_ VGHFG 436_ VYTRV 441_ SQYIE 446_ WLQKL 451_ MRSEP 456_ RPGVL 461_LRAPF
1: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (PubMed:271951)