Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12)
1_MSEVP 6_ VARVW 11_ LVLLL 16_ LTVQV 21_ GVTAG 26_ APWQC 31_ APCSA 36_ EKLAL 41_ CPPVS 46_ ASCSE 51_ VTRSA 56_ GCGCC 61_ PMCAL 66_ PLGAA 71_ CGVAT 76_ ARCAR 81_ GLSCR 86_ ALPGE 91_ QQPLH 96_ ALTRG 101_ QGACV 106_ QESDA 111_ SAPHA 116_ AEAGS 121_ PESPE 126_ STEIT 131_ EEELL 136_ DNFHL 141_ MAPSE 146_ EDHSI 151_ LWDAI 156_ STYDG 161_ SKALH 166_ VTNIK 171_ KWKEP 176_ CRIEL 181_ YRVVE 186_ SLAKA 191_ QETSG 196_ EEISK 201_ FYLPN 206_ CNKNG 211_ FYHSR 216_ QCETS 221_ MDGEA 226_ GLCWC 231_ VYPWN 236_ GKRIP 241_ GSPEI 246_ RGDPN 251_CQIYF
1: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity)