5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A)
1_MDVLS 6_ PGQGN 11_ NTTSP 16_ PAPFE 21_ TGGNT 26_ TGISD 31_ VTVSY 36_ QVITS 41_ LLLGT 46_ LIFCA 51_ VLGNA 56_ CVVAA 61_ IALER 66_ SLQNV 71_ ANYLI 76_ GSLAV 81_ TDLMV 86_ SVLVL 91_ PMAAL 96_ YQVLN 101_ KWTLG 106_ QVTCD 111_ LFIAL 116_ DVLCC 121_ TSSIL 126_ HLCAI 131_ ALDRY 136_ WAITD 141_ PIDYV 146_ NKRTP 151_ RRAAA 156_ LISLT 161_ WLIGF 166_ LISIP 171_ PMLGW 176_ RTPED 181_ RSDPD 186_ ACTIS 191_ KDHGY 196_ TIYST 201_ FGAFY 206_ IPLLL 211_ MLVLY 216_ GRIFR 221_ AARFR 226_ IRKTV 231_ KKVEK 236_ TGADT 241_ RHGAS 246_ PAPQP 251_ KKSVN 256_ GESGS 261_ RNWRL 266_ GVESK 271_ AGGAL 276_ CANGA 281_ VRQGD 286_ DGAAL 291_ EVIEV 296_ HRVGN 301_ SKEHL 306_ PLPSE 311_ AGPTP 316_ CAPAS 321_ FERKN 326_ ERNAE 331_ AKRKM 336_ ALARE 341_ RKTVK 346_ TLGII 351_ MGTFI 356_ LCWLP 361_ FFIVA 366_ LVLPF 371_ CESSC 376_ HMPTL 381_ LGAII 386_ NWLGY 391_ SNSLL 396_ NPVIY 401_ AYFNK 406_ DFQNA 411_ FKKII 416_KCKFC
1: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:38552625, PubMed:8138923, PubMed:8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:8138923, PubMed:8393041). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:33762731, PubMed:35610220). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the response to anxiogenic stimuli (PubMed:18476671, PubMed:20363322, PubMed:20945968)