Monoacylglycerol lipase ABHD2 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 2) (Acetylesterase) (EC 3.1.1.6) (Lung alpha/beta hydrolase 2) (Progesterone-sensitive lipase) (EC 3.1.1.79) (Protein PHPS1-2)
1_MNAML 6_ ETPEL 11_ PAVFD 16_ GVKLA 21_ AVAAV 26_ LYVIV 31_ RCLNL 36_ KSPTA 41_ PPDLY 46_ FQDSG 51_ LSRFL 56_ LKSCP 61_ LLTKE 66_ YIPPL 71_ IWGKS 76_ GHIQT 81_ ALYGK 86_ MGRVR 91_ SPHPY 96_ GHRKF 101_ ITMSD 106_ GATST 111_ FDLFE 116_ PLAEH 121_ CVGDD 126_ ITMVI 131_ CPGIA 136_ NHSEK 141_ QYIRT 146_ FVDYA 151_ QKNGY 156_ RCAVL 161_ NHLGA 166_ LPNIE 171_ LTSPR 176_ MFTYG 181_ CTWEF 186_ GAMVN 191_ YIKKT 196_ YPLTQ 201_ LVVVG 206_ FSLGG 211_ NIVCK 216_ YLGET 221_ QANQE 226_ KVLCC 231_ VSVCQ 236_ GYSAL 241_ RAQET 246_ FMQWD 251_ QCRRF 256_ YNFLM 261_ ADNMK 266_ KIILS 271_ HRQAL 276_ FGDHV 281_ KKPQS 286_ LEDTD 291_ LSRLY 296_ TATSL 301_ MQIDD 306_ NVMRK 311_ FHGYN 316_ SLKEY 321_ YEEES 326_ CMRYL 331_ HRIYV 336_ PLMLV 341_ NAADD 346_ PLVHE 351_ SLLTI 356_ PKSLS 361_ EKREN 366_ VMFVL 371_ PLHGG 376_ HLGFF 381_ EGSVL 386_ FPEPL 391_ TWMDK 396_ LVVEY 401_ ANAIC 406_ QWERN 411_ KLQCS 416_DTEQV
1: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity)