Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR)
1_MFRQE 6_ QPLAE 11_ GSFAP 16_ MGSLQ 21_ PDAGN 26_ ASWNG 31_ TEAPG 36_ GGARA 41_ TPYSL 46_ QVTLT 51_ LVCLA 56_ GLLML 61_ LTVFG 66_ NVLVI 71_ IAVFT 76_ SRALK 81_ APQNL 86_ FLVSL 91_ ASADI 96_ LVATL 101_ VIPFS 106_ LANEV 111_ MGYWY 116_ FGKAW 121_ CEIYL 126_ ALDVL 131_ FCTSS 136_ IVHLC 141_ AISLD 146_ RYWSI 151_ TQAIE 156_ YNLKR 161_ TPRRI 166_ KAIII 171_ TVWVI 176_ SAVIS 181_ FPPLI 186_ SIEKK 191_ GGGGG 196_ PQPAE 201_ PRCEI 206_ NDQKW 211_ YVISS 216_ CIGSF 221_ FAPCL 226_ IMILV 231_ YVRIY 236_ QIAKR 241_ RTRVP 246_ PSRRG 251_ PDAVA 256_ APPGG 261_ TERRP 266_ NGLGP 271_ ERSAG 276_ PGGAE 281_ AEPLP 286_ TQLNG 291_ APGEP 296_ APAGP 301_ RDTDA 306_ LDLEE 311_ SSSSD 316_ HAERP 321_ PGPRR 326_ PERGP 331_ RGKGK 336_ ARASQ 341_ VKPGD 346_ SLPRR 351_ GPGAT 356_ GIGTP 361_ AAGPG 366_ EERVG 371_ AAKAS 376_ RWRGR 381_ QNREK 386_ RFTFV 391_ LAVVI 396_ GVFVV 401_ CWFPF 406_ FFTYT 411_ LTAVG 416_ CSVPR 421_ TLFKF 426_ FFWFG 431_ YCNSS 436_ LNPVI 441_ YTIFN 446_ HDFRR 451_ AFKKI 456_LCRGD
1: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol