Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
1_MKNIY 6_ CLIPK 11_ LVNFA 16_ TLGCL 21_ WISVV 26_ QCTVL 31_ NSCLK 36_ SCVTN 41_ LGQQL 46_ DLGTP 51_ HNLSE 56_ PCIQG 61_ CHFWN 66_ SVDQK 71_ NCALK 76_ CRESC 81_ EVGCS 86_ SAEGA 91_ YEEEV 96_ LENAD 101_ LPTAP 106_ FASSI 111_ GSHNM 116_ TLRWK 121_ SANFS 126_ GVKYI 131_ IQWKY 136_ AQLLG 141_ SWTYT 146_ KTVSR 151_ PSYVV 156_ KPLHP 161_ FTEYI 166_ FRVVW 171_ IFTAQ 176_ LQLYS 181_ PPSPS 186_ YRTHP 191_ HGVPE 196_ TAPLI 201_ RNIES 206_ SSPDT 211_ VEVSW 216_ DPPQF 221_ PGGPI 226_ LGYNL 231_ RLISK 236_ NQKLD 241_ AGTQR 246_ TSFQF 251_ YSTLP 256_ NTIYR 261_ FSIAA 266_ VNEVG 271_ EGPEA 276_ ESSIT 281_ TSSSA 286_ VQQEE 291_ QWLFL 296_ SRKTS 301_ LRKRS 306_ LKHLV 311_ DEAHC 316_ LRLDA 321_ IYHNI 326_ TGISV 331_ DVHQQ 336_ IVYFS 341_ EGTLI 346_ WAKKA 351_ ANMSD 356_ VSDLR 361_ IFYRG 366_ SGLIS 371_ SISID 376_ WLYQR 381_ MYFIM 386_ DELVC 391_ VCDLE 396_ NCSNI 401_ EEITP 406_ PSISA 411_ PQKIV 416_ ADSYN 421_ GYVFY 426_ LLRDG 431_ IYRAD 436_ LPVPS 441_ GRCAE 446_ AVRIV 451_ ESCTL 456_ KDFAI 461_ KPQAK 466_ RIIYF 471_ NDTAQ 476_ VFMST 481_ FLDGS 486_ ASHLI 491_ LPRIP 496_ FADVK 501_ SFACE 506_ NNDFL 511_ VTDGK 516_ VIFQQ 521_ DALSF 526_ NEFIV 531_ GCDLS 536_ HIEEF 541_ GFGNL 546_ VIFGS 551_ SSQLH 556_ PLPGR 561_ PQELS 566_ VLFGS 571_ HQALV 576_ QWKPP 581_ ALAIG 586_ ANVIL 591_ ISDII 596_ ELFEL 601_ GPSAW 606_ QNWTY 611_ EVKVS 616_ TQDPP 621_ EVTHI 626_ FLNIS 631_ GTMLN 636_ VPELQ 641_ SAMKY 646_ KVSVR 651_ ASSPK 656_ RPGPW 661_ SEPSV 666_ GTTLV 671_ PASEP 676_ PFIMA 681_ VKEDG 686_ LWSKP 691_ LNSFG 696_ PGEFL 701_ SSDIG 706_ NVSDM 711_ DWYNN 716_ SLYYS 721_ DTKGD 726_ VFVWL 731_ LNGTD 736_ ISENY 741_ HLPSI 746_ AGAGA 751_ LAFEW 756_ LGHFL 761_ YWAGK 766_ TYVIQ 771_ RQSVL 776_ TGHTD 781_ IVTHV 786_ KLLVN 791_ DMVVD 796_ SVGGY 801_ LYWTT 806_ LYSVE 811_ STRLN 816_ GESSL 821_ VLQTQ 826_ PWFSG 831_ KKVIA 836_ LTLDL 841_ SDGLL 846_ YWLVQ 851_ DSQCI 856_ HLYTA 861_ VLRGQ 866_ STGDT 871_ TITEF 876_ AAWST 881_ SEISQ 886_ NALMY 891_ YSGRL 896_ FWING 901_ FRIIT 906_ TQEIG 911_ QKTSV 916_ SVLEP 921_ ARFNQ 926_ FTIIQ 931_ TSLKP 936_ LPGNF 941_ SFTPK 946_ VIPDS 951_ VQESS 956_ FRIEG 961_ NASSF 966_ QILWN 971_ GPPAV 976_ DWGVV 981_ FYSVE 986_ FSAHS 991_ KFLAS 996_ EQHSL 1001_ PVFTV 1006_ EGLEP 1011_ YALFN 1016_ LSVTP 1021_ YTYWG 1026_ KGPKT 1031_ SLSLR 1036_ APETV 1041_ PSAPE 1046_ NPRIF 1051_ ILPSG 1056_ KCCNK 1061_ NEVVV 1066_ EFRWN 1071_ KPKHE 1076_ NGVLT 1081_ KFEIF 1086_ YNISN 1091_ QSITN 1096_ KTCED 1101_ WIAVN 1106_ VTPSV 1111_ MSFQL 1116_ EGMSP 1121_ RCFIA 1126_ FQVRA 1131_ FTSKG 1136_ PGPYA 1141_ DVVKS 1146_ TTSEI 1151_ NPFPH 1156_ LITLL 1161_ GNKIV 1166_ FLDMD 1171_ QNQVV 1176_ WTFSA 1181_ ERVIS 1186_ AVCYT 1191_ ADNEM 1196_ GYYAE 1201_ GDSLF 1206_ LLHLH 1211_ NRSSS 1216_ ELFQD 1221_ SLVFD 1226_ ITVIT 1231_ IDWIS 1236_ RHLYF 1241_ ALKES 1246_ QNGMQ 1251_ VFDVD 1256_ LEHKV 1261_ KYPRE 1266_ VKIHN 1271_ RNSTI 1276_ ISFSV 1281_ YPLLS 1286_ RLYWT 1291_ EVSNF 1296_ GYQMF 1301_ YYSII 1306_ SHTLH 1311_ RILQP 1316_ TATNQ 1321_ QNKRN 1326_ QCSCN 1331_ VTEFE 1336_ LSGAM 1341_ AIDTS 1346_ NLEKP 1351_ LIYFA 1356_ KAQEI 1361_ WAMDL 1366_ EGCQC 1371_ WRVIT 1376_ VPAML 1381_ AGKTL 1386_ VSLTV 1391_ DGDLI 1396_ YWIIT 1401_ AKDST 1406_ QIYQA 1411_ KKGNG 1416_ AIVSQ 1421_ VKALR 1426_ SRHIL 1431_ AYSSV 1436_ MQPFP 1441_ DKAFL 1446_ SLASD 1451_ TVEPT 1456_ ILNAT 1461_ NTSLT 1466_ IRLPL 1471_ AKTNL 1476_ TWYGI 1481_ TSPTP 1486_ TYLVY 1491_ YAEVN 1496_ DRKNS 1501_ SDLKY 1506_ RILEF 1511_ QDSIA 1516_ LIEDL 1521_ QPFST 1526_ YMIQI 1531_ AVKNY 1536_ YSDPL 1541_ EHLPP 1546_ GKEIW 1551_ GKTKN 1556_ GVPEA 1561_ VQLIN 1566_ TTVRS 1571_ DTSLI 1576_ ISWRE 1581_ SHKPN 1586_ GPKES 1591_ VRYQL 1596_ AISHL 1601_ ALIPE 1606_ TPLRQ 1611_ SEFPN 1616_ GRLTL 1621_ LVTRL 1626_ SGGNI 1631_ YVLKV 1636_ LACHS 1641_ EEMWC 1646_ TESHP 1651_ VTVEM 1656_ FNTPE 1661_ KPYSL 1666_ VPENT 1671_ SLQFN 1676_ WKAPL 1681_ NVNLI 1686_ RFWVE 1691_ LQKWK 1696_ YNEFY 1701_ HVKTS 1706_ CSQGP 1711_ AYVCN 1716_ ITNLQ 1721_ PYTSY 1726_ NVRVV 1731_ VVYKT 1736_ GENST 1741_ SLPES 1746_ FKTKA 1751_ GVPNK 1756_ PGIPK 1761_ LLEGS 1766_ KNSIQ 1771_ WEKAE 1776_ DNGCR 1781_ ITYYI 1786_ LEIRK 1791_ STSNN 1796_ LQNQN 1801_ LRWKM 1806_ TFNGS 1811_ CSSVC 1816_ TWKSK 1821_ NLKGI 1826_ FQFRV 1831_ VAANN 1836_ LGFGE 1841_ YSGIS 1846_ ENIIL 1851_ VGDDF 1856_ WIPET 1861_ SFILT 1866_ IIVGI 1871_ FLVVT 1876_ IPLTF 1881_ VWHRR 1886_ LKNQK 1891_ SAKEG 1896_ VTVLI 1901_ NEDKE 1906_ LAELR 1911_ GLAAG 1916_ VGLAN 1921_ ACYAI 1926_ HTLPT 1931_ QEEIE 1936_ NLPAF 1941_ PREKL 1946_ TLRLL 1951_ LGSGA 1956_ FGEVY 1961_ EGTAV 1966_ DILGV 1971_ GSGEI 1976_ KVAVK 1981_ TLKKG 1986_ STDQE 1991_ KIEFL 1996_ KEAHL 2001_ MSKFN 2006_ HPNIL 2011_ KQLGV 2016_ CLLNE 2021_ PQYII 2026_ LELME 2031_ GGDLL 2036_ TYLRK 2041_ ARMAT 2046_ FYGPL 2051_ LTLVD 2056_ LVDLC 2061_ VDISK 2066_ GCVYL 2071_ ERMHF 2076_ IHRDL 2081_ AARNC 2086_ LVSVK 2091_ DYTSP 2096_ RIVKI 2101_ GDFGL 2106_ ARDIY 2111_ KNDYY 2116_ RKRGE 2121_ GLLPV 2126_ RWMAP 2131_ ESLMD 2136_ GIFTT 2141_ QSDVW 2146_ SFGIL 2151_ IWEIL 2156_ TLGHQ 2161_ PYPAH 2166_ SNLDV 2171_ LNYVQ 2176_ TGGRL 2181_ EPPRN 2186_ CPDDL 2191_ WNLMT 2196_ QCWAQ 2201_ EPDQR 2206_ PTFHR 2211_ IQDQL 2216_ QLFRN 2221_ FFLNS 2226_ IYKSR 2231_ DEANN 2236_ SGVIN 2241_ ESFEG 2246_ EDGDV 2251_ ICLNS 2256_ DDIMP 2261_ VALME 2266_ TKNRE 2271_ GLNYM 2276_ VLATE 2281_ CGQGE 2286_ EKSEG 2291_ PLGSQ 2296_ ESESC 2301_ GLRKE 2306_ EKEPH 2311_ ADKDF 2316_ CQEKQ 2321_ VAYCP 2326_ SGKPE 2331_ GLNYA 2336_ CLTHS 2341_GYGDG
1: Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2