Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]
1_MARRA 6_ GGARM 11_ FGSLL 16_ LFALL 21_ AAGVA 26_ PLSWD 31_ LPEPR 36_ SRASK 41_ IRVHS 46_ RGNLW 51_ ATGHF 56_ MGKKS 61_ LEPSS 66_ PSPLG 71_ TAPHT 76_ SLRDQ 81_ RLQLS 86_ HDLLG 91_ ILLLK 96_ KALGV 101_ SLSRP 106_ APQIQ 111_ YRRLL 116_VQILQ
1: Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity)