CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)
1_MAVEG 6_ GMKCV 11_ KFLLY 16_ VLLLA 21_ FCACA 26_ VGLIA 31_ VGVGA 36_ QLVLS 41_ QTIIQ 46_ GATPG 51_ SLLPV 56_ VIIAV 61_ GVFLF 66_ LVAFV 71_ GCCGA 76_ CKENY 81_ CLMIT 86_ FAIFL 91_ SLIML 96_ VEVAA 101_ AIAGY 106_ VFRDK 111_ VMSEF 116_ NNNFR 121_ QQMEN 126_ YPKNN 131_ HTASI 136_ LDRMQ 141_ ADFKC 146_ CGAAN 151_ YTDWE 156_ KIPSM 161_ SKNRV 166_ PDSCC 171_ INVTV 176_ GCGIN 181_ FNEKA 186_ IHKEG 191_ CVEKI 196_ GGWLR 201_ KNVLV 206_ VAAAA 211_ LGIAF 216_ VEVLG 221_ IVFAC 226_ CLVKS 231_IRSGY
1: Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli