Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)
1_MVGVG 6_ GGDVE 11_ DVTPR 16_ PGGCQ 21_ ISGRG 26_ ARGCN 31_ GIPGA 36_ AAWEA 41_ ALPRR 46_ RPRRH 51_ PSVNP 56_ RSRAA 61_ GSPRT 66_ RGRRT 71_ EERPS 76_ GSRLG 81_ DRGRG 86_ RALPG 91_ GRLGG 96_ RGRGR 101_ APERV 106_ GGRGR 111_ GRGTA 116_ APRAA 121_ PAARG 126_ SRPGP 131_ AGTMA 136_ AGSIT 141_ TLPAL 146_ PEDGG 151_ SGAFP 156_ PGHFK 161_ DPKRL 166_ YCKNG 171_ GFFLR 176_ IHPDG 181_ RVDGV 186_ REKSD 191_ PHIKL 196_ QLQAE 201_ ERGVV 206_ SIKGV 211_ CANRY 216_ LAMKE 221_ DGRLL 226_ ASKCV 231_ TDECF 236_ FFERL 241_ ESNNY 246_ NTYRS 251_ RKYTS 256_ WYVAL 261_ KRTGQ 266_ YKLGS 271_ KTGPG 276_ QKAIL 281_FLPMS
1: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879)