U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C)
1_MPKFY 6_ CDYCD 11_ TYLTH 16_ DSPSV 21_ RKTHC 26_ SGRKH 31_ KENVK 36_ DYYQK 41_ WMEEQ 46_ AQSLI 51_ DKTTA 56_ AFQQG 61_ KIPPT 66_ PFSAP 71_ PPAGA 76_ MIPPP 81_ PSLPG 86_ PPRPG 91_ MMPAP 96_ HMGGP 101_ PMMPM 106_ MGPPP 111_ PGMMP 116_ VGPAP 121_ GMRPP 126_ MGGHM 131_ PMMPG 136_ PPMMR 141_ PPARP 146_ MMVPT 151_RPGMT
1: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region