Villin-1
1_MTKLS 6_ AQVKG 11_ SLNIT 16_ TPGLQ 21_ IWRIE 26_ AMQMV 31_ PVPSS 36_ TFGSF 41_ FDGDC 46_ YIILA 51_ IHKTA 56_ SSLSY 61_ DIHYW 66_ IGQDS 71_ SLDEQ 76_ GAAAI 81_ YTTQM 86_ DDFLK 91_ GRAVQ 96_ HREVQ 101_ GNESE 106_ AFRGY 111_ FKQGL 116_ VIRKG 121_ GVASG 126_ MKHVE 131_ TNSYD 136_ VQRLL 141_ HVKGK 146_ RNVVA 151_ GEVEM 156_ SWKSF 161_ NRGDV 166_ FLLDL 171_ GKLII 176_ QWNGP 181_ ESTRM 186_ ERLRG 191_ MTLAK 196_ EIRDQ 201_ ERGGR 206_ TYVGV 211_ VDGEN 216_ ELASP 221_ KLMEV 226_ MNHVL 231_ GKRRE 236_ LKAAV 241_ PDTVV 246_ EPALK 251_ AALKL 256_ YHVSD 261_ SEGNL 266_ VVREV 271_ ATRPL 276_ TQDLL 281_ SHEDC 286_ YILDQ 291_ GGLKI 296_ YVWKG 301_ KKANE 306_ QEKKG 311_ AMSHA 316_ LNFIK 321_ AKQYP 326_ PSTQV 331_ EVQND 336_ GAESA 341_ VFQQL 346_ FQKWT 351_ ASNRT 356_ SGLGK 361_ THTVG 366_ SVAKV 371_ EQVKF 376_ DATSM 381_ HVKPQ 386_ VAAQQ 391_ KMVDD 396_ GSGEV 401_ QVWRI 406_ ENLEL 411_ VPVDS 416_ KWLGH 421_ FYGGD 426_ CYLLL 431_ YTYLI 436_ GEKQH 441_ YLLYV 446_ WQGSQ 451_ ASQDE 456_ ITASA 461_ YQAVI 466_ LDQKY 471_ NGEPV 476_ QIRVP 481_ MGKEP 486_ PHLMS 491_ IFKGR 496_ MVVYQ 501_ GGTSR 506_ TNNLE 511_ TGPST 516_ RLFQV 521_ QGTGA 526_ NNTKA 531_ FEVPA 536_ RANFL 541_ NSNDV 546_ FVLKT 551_ QSCCY 556_ LWCGK 561_ GCSGD 566_ EREMA 571_ KMVAD 576_ TISRT 581_ EKQVV 586_ VEGQE 591_ PANFW 596_ MALGG 601_ KAPYA 606_ NTKRL 611_ QEENL 616_ VITPR 621_ LFECS 626_ NKTGR 631_ FLATE 636_ IPDFN 641_ QDDLE 646_ EDDVF 651_ LLDVW 656_ DQVFF 661_ WIGKH 666_ ANEEE 671_ KKAAA 676_ TTAQE 681_ YLKTH 686_ PSGRD 691_ PETPI 696_ IVVKQ 701_ GHEPP 706_ TFTGW 711_ FLAWD 716_ PFKWS 721_ NTKSY 726_ EDLKA 731_ ELGNS 736_ RDWSQ 741_ ITAEV 746_ TSPKV 751_ DVFNA 756_ NSNLS 761_ SGPLP 766_ IFPLE 771_ QLVNK 776_ PVEEL 781_ PEGVD 786_ PSRKE 791_ EHLSI 796_ EDFTQ 801_ AFGMT 806_ PAAFS 811_ ALPRW 816_ KQQNL 821_KKEKG
1: Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination