Glycodelin (GD) (Placental protein 14) (PP14) (Pregnancy-associated endometrial alpha-2 globulin) (PAEG) (PEG) (Progestagen-associated endometrial protein) (Progesterone-associated endometrial protein) (Zona-binding inhibitory factor-1) (ZIF-1)
1_MLCLL 6_ LTLGV 11_ ALVCG 16_ VPAMD 21_ IPQTK 26_ QDLEL 31_ PKLAG 36_ TWHSM 41_ AMATN 46_ NISLM 51_ ATLKA 56_ PLRVH 61_ ITSLL 66_ PTPED 71_ NLEIV 76_ LHRWE 81_ NNSCV 86_ EKKVL 91_ GEKTE 96_ NPKKF 101_ KINYT 106_ VANEA 111_ TLLDT 116_ DYDNF 121_ LFLCL 126_ QDTTT 131_ PIQSM 136_ MCQYL 141_ ARVLV 146_ EDDEI 151_ MQGFI 156_ RAFRP 161_ LPRHL 166_ WYLLD 171_LKQME
1: Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:7531163, PubMed:9918684). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155)