Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)
1_MADQA 6_ PFDTD 11_ VNTLT 16_ RFVME 21_ EGRKA 26_ RGTGE 31_ LTQLL 36_ NSLCT 41_ AVKAI 46_ SSAVR 51_ KAGIA 56_ HLYGI 61_ AGSTN 66_ VTGDQ 71_ VKKLD 76_ VLSND 81_ LVMNM 86_ LKSSF 91_ ATCVL 96_ VSEED 101_ KHAII 106_ VEPEK 111_ RGKYV 116_ VCFDP 121_ LDGSS 126_ NIDCL 131_ VSVGT 136_ IFGIY 141_ RKKST 146_ DEPSE 151_ KDALQ 156_ PGRNL 161_ VAAGY 166_ ALYGS 171_ ATMLV 176_ LAMDC 181_ GVNCF 186_ MLDPA 191_ IGEFI 196_ LVDKD 201_ VKIKK 206_ KGKIY 211_ SLNEG 216_ YARDF 221_ DPAVT 226_ EYIQR 231_ KKFPP 236_ DNSAP 241_ YGARY 246_ VGSMV 251_ ADVHR 256_ TLVYG 261_ GIFLY 266_ PANKK 271_ SPNGK 276_ LRLLY 281_ ECNPM 286_ AYVME 291_ KAGGM 296_ ATTGK 301_ EAVLD 306_ VIPTD 311_ IHQRA 316_ PVILG 321_ SPDDV 326_ LEFLK 331_VYEKH
1: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain